INI-1 (MRQ-27) Mouse Monoclonal Antibody

INI-1
INI-1 antibody shows nuclear reaction in neuronal cells in the brain.

INI-1 (MRQ-27) Mouse Monoclonal Antibody

Specialties: Pediatric Pathology

Updated: 2018-01-11 09:28:41

The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1 that differ by the variable inclusion of amino acids are potentially produced by differential RNA splicing.

The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics [medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs)] is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.1-3

  1. Bourdeaut F, et al. hSNF5/INI1-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities. J Pathol. 2007; 211:323-30.
  2. Fowler DJ, et al. Primary thoracic myxoid variant of extrarenal rhabdoid tumor in childhood. Fetal Pediatr Pathol. 2006; 25:159-68.
  3. Haberler C, et al. Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: Lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotype. Am J SurgPathol. 2006; 30:1462-8.

Specifications


  • Reactivity: paraffin
  • Control: Brain (Nuclear); Endothelial cells (Nuclear); Astrocytoma (Nuclear)
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate272M-14
0.5 mL concentrate272M-15
1.0 mL concentrate272M-16
1.0 mL predilute ready-to-use272M-17
7.0 mL predilute ready-to-use272M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate272M-14
0.5 mL concentrate272M-15
1.0 mL concentrate272M-16
1.0 mL predilute ready-to-use272M-17
7.0 mL predilute ready-to-use272M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate272M-14
0.5 mL concentrate272M-15
1.0 mL concentrate272M-16
1.0 mL predilute ready-to-use272M-17
7.0 mL predilute ready-to-use272M-18

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)272M-14-RUO
0.5 mL concentrate (RUO)272M-15-RUO
1.0 mL concentrate (RUO)272M-16-RUO
1.0 mL predilute ready-to-use (RUO)272M-17-RUO
7.0 mL predilute ready-to-use (RUO)272M-18-RUO

 

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