CD31 (JC70) Mouse Monoclonal Antibody

CD31
CD31 (JC70) on tonsil.

CD31 (JC70) Mouse Monoclonal Antibody

Specialties: Hematopathology Soft Tissue Pathology

Updated: 2017-05-24 08:46:09

CD31 has cytoplasmic, membranous expression in non-neoplastic and neoplastic vascular endothelial cells.1 It has been used as a tool to identify the vascular origin of neoplasms such as angiosarcomas, Kaposi sarcomas and epithelioid hemangioendothelioma.1,2  Immunohistochemical study with CD31 has also been shown useful to detect areas of tumor lymphovascular invasion.3 Additionally, detection of weak diffuse cytoplasmic CD31 immunoreactivity has been seen in cases of various carcinomas with occasional  membranous staining in ductal carcinomas of the breast as well as in intratumoral macrophages.4,5

  1. Parums DV, et al. JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol. 1990; 43:752-7.
  2. Attanoos RL, et al. Malignant vascular tumors of the pleura in “asbestos” workers and endothelial differentiation in malignant mesothelioma. Thorax. 2000; 55:860-3.
  3. Alexander-Sefre F, et al. Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry. J Clin Pathol. 2003; 56:786-8.
  4. Ortiz-Hidaldo C, et al. CD31 with strong membrane-based immunoreactivity in ductal carcinoma of the breast. Appl Immunohistochem Mol Morphol. 2000; 8: 334-5.
  5. McKenney JK, et al. CD 31 expression in intratumoral macrophages: a potential diagnostic pitfall. Am J of Surg Pathol. 2001; 25:1167-73.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: tonsil
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate131M-94
0.5 mL concentrate131M-95
1 mL concentrate131M-96
1 mL predilute131M-97
7 mL predilute131M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate131M-94
0.5 mL concentrate131M-95
1 mL concentrate131M-96
1 mL predilute131M-97
7 mL predilute131M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate131M-94
0.5 mL concentrate131M-95
1 mL concentrate131M-96
1 mL predilute131M-97
7 mL predilute131M-98

For research use only (RUO) in Japan

0.1 mL concentrate131M-94-RUO
0.5 mL concentrate131M-95-RUO
1 mL concentrate131M-96-RUO
1 mL predilute131M-97-RUO
7 mL predilute131M-98-RUO

 

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