MART-1 (Melan A) (M2-7C10) Mouse Monoclonal Antibody

MART-1 (Melan A)
Anti-MART-1 (M2-7C10) demonstrates strong cytoplasmic reaction in this metastatic melanoma.

MART-1 (Melan A) (M2-7C10) Mouse Monoclonal Antibody

Specialties: Dermatopathology

Updated: 2017-05-24 08:46:09

MART-1 (also known as Melan A) is a melanocyte differentiation antigen.1-2  MART-1 is a transmembrane protein present in melanocytes of normal skin, retina, nevi, and most melanomas. MART-1 is a very useful marker for identifying metastatic melanomas.3-11

  1. Kawakam Y, et al. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. Natl. Acad. Sci. U S A. 1994; 91: 3515-19.
  2. Couli PG, et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med. 1994; 180: 35-42.
  3. Kageshita T, et al. Differential expression of MART-1 in primary and metastatic melanoma lesions. J Immunother. 1997; 20:460-5.
  4. Fetsch PA, et al. Melanoma-associated antigen recognized by T cells (MART-1): the advent of a preferred immunocytochemical antibody for the diagnosis of metastatic malignant melanoma with fine-needle aspiration. Cancer. 1999; 87:37-42.
  5. Bergman R, et al. A comparative immunohistochemical study of MART-1 expression in Spitz nevi, ordinary melanocytic nevi, and malignant melanomas. J Am Acad Dermatol. 2000; 42:496-500.
  6. Orosz Z. Melan-A/Mart-1 expression in various melanocytic lesions and in non-melanocytic soft tissue tumours. Histopathology. 1999; 34:517-25.
  7. Yaziji H, et al. Immunohistochemical markers of melanocytic tumors. Int J Surg Pathol. 2003; 11:11-5.
  8. Suchak R, et al. Evaluation of the role of routine melan-A immunohistochemistry for exclusion of microinvasion in 120 cases of lentigo maligna. Am J Dermatopathol. 2014; 36:387-91.
  9. Helm K et al. Immunohistochemistry of pigmented actinic keratoses, actinic keratoses, melanomas in situ and solar lentigines with Melan-A. J Cutan Pathol. 2008; 35:931-4.
  10. Kucher C, et al. Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi. Am J Dermatopathol. 2004; 26:452-7.
  11. Nielsen PS, et al. Immunohistochemical double stains against Ki67/MART1 and HMB45/MITF: promising diagnostic tools in melanocytic lesions. Am J Dermatopathol. 2011; 33:361-70.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: melanoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute281M-90
0.1 mL concentrate281M-94
0.5 mL concentrate281M-95
1 mL concentrate281M-96
1 mL predilute281M-97
7 mL predilute281M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute281M-90
0.1 mL concentrate281M-94
0.5 mL concentrate281M-95
1 mL concentrate281M-96
1 mL predilute281M-97
7 mL predilute281M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute281M-90
0.1 mL concentrate281M-94
0.5 mL concentrate281M-95
1 mL concentrate281M-96
1 mL predilute281M-97
7 mL predilute281M-98

For research use only (RUO) in Japan

25 mL predilute281M-90-RUO
0.1 mL concentrate281M-94-RUO
0.5 mL concentrate281M-95-RUO
1 mL concentrate281M-96-RUO
1 mL predilute281M-97-RUO
7 mL predilute281M-98-RUO

 

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