Inhibin, alpha (R1) Mouse Monoclonal Antibody

Inhibin, alpha
Granulosa cells in the ovary are strongly highlighted by the inhibin antibody with cytoplasmic staining.

Inhibin, alpha (R1) Mouse Monoclonal Antibody

Specialties: Genitourinary (GU) Pathology

Updated: 2017-05-24 08:46:09

Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary.1-2 Inhibin is a dimer that consists of an alpha and beta subunit.1-2 In normal tissue, anti-inhibin alpha labels granulosa cells of the ovary, sertoli and leydig cells of the testis, and the zona reticularis of the adrenal cortex.2 Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors.3-9

  1. Munro LM, et al. The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. J Endocrinol. 1999; 161:341-7.
  2. McCluggage WG, et al. Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. J Clin Pathol. 1998; 51: 114-6.
  3. Stewart CJ, et al. Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics. Histopathology. 1997; 31:67-74.
  4. Yamashita K, et al. Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors. Am J Obstet Gynecol. 1997; 177:1450-7.
  5. McCluggage WG, et al. Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. Am J Surg Pathol. 1998; 22:615-9.
  6. Kommoss F, et al. Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. Mod Pathol. 1998; 11:656-64.
  7. Iczkowski KA, et al. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol. 1998; 11:774-9.
  8. Guerrieri C, et al. Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. Int J Gynecol Pathol. 1998; 17:266-71.
  9. McCluggage WG. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol. 2000; 53:327-34.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: adrenal cortex
  • Dilution Range: 1:5-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate271M-14
0.5 mL concentrate271M-15
1 mL concentrate271M-16
1 mL predilute271M-17
7 mL predilute271M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate271M-14
0.5 mL concentrate271M-15
1 mL concentrate271M-16
1 mL predilute271M-17
7 mL predilute271M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate271M-14
0.5 mL concentrate271M-15
1 mL concentrate271M-16
1 mL predilute271M-17
7 mL predilute271M-18

For research use only (RUO) in Japan

0.1 mL concentrate271M-14-RUO
0.5 mL concentrate271M-15-RUO
1 mL concentrate271M-16-RUO
1 mL predilute271M-17-RUO
7 mL predilute271M-18-RUO

 

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