Cathepsin K (3F9) Mouse Monoclonal Antibody

Cathepsin K
Cathepsin K (3F9) on soft tissue.

Cathepsin K (3F9) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Cathepsin K is a papain-like cysteine protease that plays an important role in osteoclast function and has been identified as a target of the MiTF transcription factor family.1 Cathepsin K expression has been observed in translocation renal cell carcinoma (RCC), while other subtypes of RCC such as clear cell RCC do not react.2 Anti-Cathepsin K has been reported as a useful marker for several of the MiTF family of tumors including translocation RCC, melanoma and alveolar soft part sarcoma.3

  1. Motyckova G, et al. Linking osteopetrosis and pycnodysostosis: Regulation of cathepsin K expression by the microphthalmia transcription factor family. Proc Natl Acad Sci USA. 2001; 98:5798-803.
  2. Martignoni G, et al. Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas. Mod Pathol. 2009; 22:1016-22.
  3. Rao Q, et al. Cathepsin K in the immunohistochemical diagnosis of melanocytic lesions. Int J Clin Exp Pathol. 2014; 7:1132-9.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: Xp11.2 translocation RCC
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate402M-14
0.5 mL concentrate402M-15
1 mL concentrate402M-16
1 mL predilute402M-17
7 mL predilute402M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate402M-14
0.5 mL concentrate402M-15
1 mL concentrate402M-16
1 mL predilute402M-17
7 mL predilute402M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate402M-14
0.5 mL concentrate402M-15
1 mL concentrate402M-16
1 mL predilute402M-17
7 mL predilute402M-18

For research use only (RUO) in Japan

0.1 mL concentrate402M-14-RUO
0.5 mL concentrate402M-15-RUO
1 mL concentrate402M-16-RUO
1 mL predilute402M-17-RUO
7 mL predilute402M-18-RUO

 

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