Cell Marque Portfolio

PAX-8 (MRQ-50)

Mouse Monoclonal


PAX-8 is a transcription factor expressed during embryonic development of Müllerian organs, kidney, and thyroid, with continued expression in some epithelial cell types of these mature tissues.1   It can be useful for marking several types of carcinoma including ovarian serous carcinoma, clear cell renal cell carcinoma, and papillary thyroid carcinoma.1-5  Additionally, PAX-8 is not found in the epithelial cells of the breast, lung, mesothelium, stomach, colon, pancreas and other sites.1-4

Specialties: Anatomic Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: ovarian carcinoma (non-mucinous carcinoma), thyroid carcinoma, renal cell carcinoma
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C
  • Leica Bond
    Protocol F: ER2/10

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Keycode Specific IFU

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References


  1. Ozcan A, et al. PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 2011; 24:751-64.
  2. Laury AR, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011; 35:816-26.
  3. Nonaka, D et al. Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol. 2008; 32:1566-71.
  4. Nonaka, D et al. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (Fox E1) in thyroid epithelial neoplasms. Mod Pathol .2008; 21:192-200.
  5. Tong, GX et al. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol. 2009; 22:1218-27.

Last updated: 2017-05-24 08:46:09

PAX-8
PAX-8 antibody labels the tumor nuclei in clear cell renal cell carcinoma.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: ovarian carcinoma (non-mucinous carcinoma), thyroid carcinoma, renal cell carcinoma
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C
  • Leica Bond
    Protocol F: ER2/10

References


  1. Ozcan A, et al. PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 2011; 24:751-64.
  2. Laury AR, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011; 35:816-26.
  3. Nonaka, D et al. Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol. 2008; 32:1566-71.
  4. Nonaka, D et al. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (Fox E1) in thyroid epithelial neoplasms. Mod Pathol .2008; 21:192-200.
  5. Tong, GX et al. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol. 2009; 22:1218-27.

Download an IFU

Select revision:


Download SDS


Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 363M-14
0.5 ml, concentrate 363M-15
1 ml, concentrate 363M-16
1 ml, predilute 363M-17
7 ml, predilute 363M-18
25 ml, predilute 363M-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 363M-14
0.5 ml, concentrate 363M-15
1 ml, concentrate 363M-16
1 ml, predilute 363M-17
7 ml, predilute 363M-18
25 ml, predilute 363M-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 363M-14
0.5 ml, concentrate 363M-15
1 ml, concentrate 363M-16
1 ml, predilute 363M-17
7 ml, predilute 363M-18
25 ml, predilute 363M-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 363M-14-RUO
0.5 ml, concentrate 363M-15-RUO
1 ml, concentrate 363M-16-RUO
1 ml, predilute 363M-17-RUO
7 ml, predilute 363M-18-RUO
25 ml, predilute 363M-10-RUO

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: ovarian carcinoma (non-mucinous carcinoma), thyroid carcinoma, renal cell carcinoma
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C
  • Leica Bond
    Protocol F: ER2/10

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

Download SDS

References


  1. Ozcan A, et al. PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 2011; 24:751-64.
  2. Laury AR, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011; 35:816-26.
  3. Nonaka, D et al. Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol. 2008; 32:1566-71.
  4. Nonaka, D et al. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (Fox E1) in thyroid epithelial neoplasms. Mod Pathol .2008; 21:192-200.
  5. Tong, GX et al. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol. 2009; 22:1218-27.
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