WT1 (6F-H2) Mouse Monoclonal Antibody

WT1
Nuclear labelling of cells of mesothelioma by WT1 antibody.

WT1 (6F-H2) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2021-02-01 14:49:15

Wilms’ tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed in tissues of mesodermal origin.1 The Wilms’ tumor gene encodes a protein that functions as a tumor suppressor gene mapped to human chromosome 11p13.2  Nuclear WT1 immunoreactivity has been observed in high frequencies in several types of mesoderm-derived tumors including epithelioid mesothelioma and ovarian serous carcinoma, and thus is used as a marker for these neoplasms.2,3,6

  1. May RJ, et al. Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin Cancer Res. 2007; 13: 4547-55.
  2. Ghanem MA, et al. Expression and prognostic value of Wilms' tumor 1 and early growth response 1 proteins in nephroblastoma. Clin Cancer Res 2000; 6(11):4265-71.
  3. Al-Hussaini M, et al. WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma. Histopathology 2004; 44(2):109-15.
  4. Maki T, et al. Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification. Int J Oncol 2017; 50(1):129-140.
  5. Galfione SK, et al. Diagnostic utility of WT-1 cytoplasmic stain in variety of vascular lesions. Int J Clin Exp Pathol 2014; 7(5):2536-43.
  6. Kobel M, et al. An immunohistochemical algorithm for ovarian carcinoma typing. Int J Gynecol Pathol 2016; 35(5):430-41

Specifications


  • Reactivity: paraffin
  • Control: Ovarian serous carcinoma (Nuclear); Mesothelioma (Nuclear); Kidney (Nuclear); Testis (Nuclear)
  • Dilution Range: 1:100-1:500 *

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Ordering Information

For in vitro diagnostic (IVD) use in USA

25.0 mL predilute ready-to-use348M-90
0.1 mL concentrate348M-94
0.5 mL concentrate348M-95
1.0 mL concentrate348M-96
1.0 mL predilute ready-to-use348M-97
7.0 mL predilute ready-to-use348M-98

For in vitro diagnostic (IVD) use in Canada

25.0 mL predilute ready-to-use348M-90
0.1 mL concentrate348M-94
0.5 mL concentrate348M-95
1.0 mL concentrate348M-96
1.0 mL predilute ready-to-use348M-97
7.0 mL predilute ready-to-use348M-98

For in vitro diagnostic (IVD) use in Europe

25.0 mL predilute ready-to-use348M-90
0.1 mL concentrate348M-94
0.5 mL concentrate348M-95
1.0 mL concentrate348M-96
1.0 mL predilute ready-to-use348M-97
7.0 mL predilute ready-to-use348M-98

For research use only (RUO) in Japan

25.0 mL predilute ready-to-use (RUO)348M-90-RUO
0.1 mL concentrate (RUO)348M-94-RUO
0.5 mL concentrate (RUO)348M-95-RUO
1.0 mL concentrate (RUO)348M-96-RUO
1.0 mL predilute ready-to-use (RUO)348M-97-RUO
7.0 mL predilute ready-to-use (RUO)348M-98-RUO

 

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