WT1 (6F-H2) Mouse Monoclonal Antibody

WT1
Nuclear labelling of cells of mesothelioma by WT1 antibody.

WT1 (6F-H2) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Wilms’ tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed in tissues of mesodermal origin.1 The Wilms’ tumor gene encodes a protein that functions as a tumor suppressor gene.2  WT1 is detected in tumor cells of Wilms’ Tumor (also  known as nephroblastoma) and mesothelioma.3 Additionally, WT1 expression has been found in ovarian serous carcinomas4 and some breast carcinomas.1

  1. May RJ, et al. Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin Cancer Res. 2007; 13: 4547-55.
  2. Foster MR, et al. Immunohistochemical analysis of nuclear versus cytoplasmic staining of WT1 in malignant mesotheliomas and primary pulmonary adenocarcinomas. Arch Pathol Lab Med. 2001; 125:1316-20.
  3. Nakatsuka S, et al. Immunohistochemical detection of WT1 protein in a variety of cancer cells. Mod Pathol. 2006; 19:804-14.
  4. Goldstein NS, et al. WT1 immunoreactivity in uterine papillary serous carcinomas is different from ovarian serous carcinomas. Am J Clin Pathol. 2002; 117:541-5.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: ovarian serous carcinoma, mesothelioma, kidney, testis
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute348M-90
0.1 mL concentrate348M-94
0.5 mL concentrate348M-95
1 mL concentrate348M-96
1 mL predilute348M-97
7 mL predilute348M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute348M-90
0.1 mL concentrate348M-94
0.5 mL concentrate348M-95
1 mL concentrate348M-96
1 mL predilute348M-97
7 mL predilute348M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute348M-90
0.1 mL concentrate348M-94
0.5 mL concentrate348M-95
1 mL concentrate348M-96
1 mL predilute348M-97
7 mL predilute348M-98

For research use only (RUO) in Japan

25 mL predilute348M-90-RUO
0.1 mL concentrate348M-94-RUO
0.5 mL concentrate348M-95-RUO
1 mL concentrate348M-96-RUO
1 mL predilute348M-97-RUO
7 mL predilute348M-98-RUO

 

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Literature

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