p53 (SP5) Rabbit Monoclonal Antibody

p53
Nuclear staining of tumor cells by p53 antibody in colon adenocarcinoma.

p53 (SP5) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Anti-p53 tumor suppressor protein antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild type p53.1  Positive nuclear staining with this antibody has been shown to be a factor in breast carcinoma, lung carcinoma, colorectal carcinoma, urothelial carcinoma, and ependymoma.2-8 Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma, as well as a marker for intratubular germ cell neoplasia.9

  1. Dabbs DJ. Diagnostic Immunohistochemistry. Third Edition. Saunders. 2006.
  2. Mayall FG, et al. P-53 immunostaining in the distinction between benign and malignant mesothelial proliferations using formalin-fixed paraffin sections. J Pathol. 1992; 168:377-81.
  3. Caffo O, et al. Prognostic value of p21(WAF1) and p53 expression in breast carcinoma: an immunohistochemical study in 261 patients with long-term follow-up. Clin Cancer Res. 1996; 2:1591-9.
  4. Bebenek M, et al. Prospective studies of p53 and c-erbB-2 expression in relation to clinicopathological parameters of human ductal breast cancer in the second stage of clinical advancement. Anticancer Res. 1998; 18:619-23.
  5. Midulla C, et al. Immunohistochemical expression of p53, nm23-HI, Ki67 and DNA ploidy: correlation with lymph node status and other clinical pathologic parameters in breast cancer. Anticancer Res. 1999; 19:4033-7.
  6. Van den Berg FM, et al. Detection of p-53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid. Am J Pathol. 1993; 142:381-5.
  7. Zen ZS, et al. p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients. J Clin Oncol. 1994; 12:2043-50.
  8. Korshunov A, et al. Immunohistochemical markers for intracranial ependymoma recurrence. An analysis of 88 cases. J Neurol Sci. 2000; 177:72-82.
  9. Moore BE, et al. p53: a good diagnostic marker for intratubular germ cell neoplasia, unclassified. Appl Immunohistochem Mol Morphol. 2001; 9:203-6.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon carcinoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate453R-14
0.5 mL concentrate453R-15
1 mL concentrate453R-16
1 mL predilute453R-17
7 mL predilute453R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate453R-14
0.5 mL concentrate453R-15
1 mL concentrate453R-16
1 mL predilute453R-17
7 mL predilute453R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate453R-14
0.5 mL concentrate453R-15
1 mL concentrate453R-16
1 mL predilute453R-17
7 mL predilute453R-18

For research use only (RUO) in Japan

0.1 mL concentrate453R-14-RUO
0.5 mL concentrate453R-15-RUO
1 mL concentrate453R-16-RUO
1 mL predilute453R-17-RUO
7 mL predilute453R-18-RUO

 

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