IgG4 (MRQ-44) Mouse Monoclonal Antibody

IgG4
IgG4 monoclonal antibody stains IgG4 containing plasma cells in a cytoplasmic reaction.

IgG4 (MRQ-44) Mouse Monoclonal Antibody

Specialties: Gastrointestinal (GI) Pathology Anatomic Pathology

Updated: 2017-05-24 08:46:09

IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. Clinical manifestations are apparent in the pancreas, bile duct, gall bladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibit significantly more than normal IgG4-positive plasma cells in affected tissues but also significantly higher IgG4/IgG ratios (typically > 30%).1-8

  1. Sakata N, et al., Am J Surg Pathol. 2008; 32:553-9.
  2. Dhobale S, et al., J Clin Rheumatol. 2009; 15:354-7.
  3. Li Y, et al., Pathol Int. 2009; 59:636-41.
  4. Cheuk W, et al., Am J Surg Pathol. 2009; 33:1058-64.
  5. Deshpande V, et al., Mod Pathol. 2009; 22:1287-95.
  6. Sato Y, et al., Mod Pathol. 2009; 22: 589-99.
  7. Koyabu M et al., J Gastroenterol. 2010; 45:732-41.
  8. Kamisawa T, et al., World J Gastroenterol. 2009; 21:2357-60.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate367M-14
0.5 mL concentrate367M-15
1 mL concentrate367M-16
1 mL predilute367M-17
7 mL predilute367M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate367M-14
0.5 mL concentrate367M-15
1 mL concentrate367M-16
1 mL predilute367M-17
7 mL predilute367M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate367M-14
0.5 mL concentrate367M-15
1 mL concentrate367M-16
1 mL predilute367M-17
7 mL predilute367M-18

For research use only (RUO) in Japan

0.1 mL concentrate367M-14-RUO
0.5 mL concentrate367M-15-RUO
1 mL concentrate367M-16-RUO
1 mL predilute367M-17-RUO
7 mL predilute367M-18-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information