Kappa (L1C1) Mouse Monoclonal Antibody

Kappa
Kappa (L1C1) on plasmacytoma.

Kappa (L1C1) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

Anti-Kappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chain ratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder exists. Monoclonality is determined by a kappa-lambda ratio of greater than or equal to 3:1 or a lambda-kappa ratio greater than 2:1.1-3

  1. Ashton-Key M, et al. Histopathology. 1996; 29:525-31.
  2. Kurtin PJ, et al. Am J Clin Pathol. 1999; 112:319-29.
  3. Abbondanzo SL, et al. Ann Diagn Pathol. 1999; 3:318-27.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute274M-90
0.1 mL concentrate274M-94
0.5 mL concentrate274M-95
1 mL concentrate274M-96
1 mL predilute274M-97
7 mL predilute274M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute274M-90
0.1 mL concentrate274M-94
0.5 mL concentrate274M-95
1 mL concentrate274M-96
1 mL predilute274M-97
7 mL predilute274M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute274M-90
0.1 mL concentrate274M-94
0.5 mL concentrate274M-95
1 mL concentrate274M-96
1 mL predilute274M-97
7 mL predilute274M-98

For research use only (RUO) in Japan

0.1 mL concentrate274M-94-RUO
0.5 mL concentrate274M-95-RUO
1 mL concentrate274M-96-RUO
1 mL predilute274M-97-RUO
7 mL predilute274M-98-RUO

 

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