DAX-1 (NR0B1) (EP358) Rabbit Monoclonal Antibody

DAX-1 (NR0B1)
Ewing's sarcoma stained with anti-human DAX-1

DAX-1 (NR0B1) (EP358) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

Nuclear receptor DAX-1, encoded by the gene NR0B1, is a member of the orphan nuclear receptor family that functions as a global negative regulator of steroid hormone production. DAX-1 negatively regulates steroid production as a transcriptional repressor or corepressor by repressing the expression of steroidogenic acute regulatory protein (STAR) in the adrenal cortex and gonads. DAX-1 expression is restricted to steroidogenic tissues such as the adrenal cortex, ovary, testis and other endocrine tissues.

In human neoplasms, DAX-1 has been examined in several types of tumors. Studies have demonstrated DAX-1 expression in adrenocortical, breast, and ovarian carcinomas. In operable node-negative breast cancer, high DAX-1 expression was correlated with increased survival. However, DAX-1 immunoreactivity was associated with poor prognosis in ovarian carcinoma. Also, the NR0B1 gene was found to be necessary for oncogenic transformation of Ewing’s sarcoma, it is highly expressed in Ewing’s sarcoma but not in other histologically similar small round cell tumors such as neuroblastoma and embryonal rhabdomyosarcoma.

Specifications


  • Dilution Range: 1:20*

Package Inserts


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Ordering Information

For research use only (RUO) in USA

0.1 mL concentrateAC-0330RUO
1 mL concentrateAC-0330RUOC

This product is not available in Canada

For research use only (RUO) in the EU

0.1 mL concentrateAC-0330RUO
1 mL concentrateAC-0330RUOC

For research use only (RUO) in Japan

0.1 mL concentrateAC-0330RUO
1 mL concentrateAC-0330RUOC

 

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