S100A4 (EP360) Rabbit Monoclonal Antibody

S100A4
Tonsil stained with anti-human S100A4

S100A4 (EP360) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

S100 calcium-binding protein A4 (S100A4) is a member of the S100 family of calcium binding proteins. S100A4 is encoded with other S100 family members on chromosome 1q21. This protein has been suggested in modulating cellular functions such motility, invasion, cell cycle progression and differentiation. In vitro studies demonstrated S100A4 interaction with the C terminus of p53 to promote degradation and inhibition of protein kinase C phosphorylation.

S100A4 has been shown to be a prognostic marker in a number of human cancers, including carcinomas of breast, esophagus, lung, gastric, prostate, bladder and pancreas. Immunohistochemical analysis shows elevated S100A4 expression compared with normal tissue. Carcinomas that stain positively for S100A4 expression are highly correlated with poor prognosis, suggesting that enhanced S100A4 expression contributes to manifestation of a metastatic phenotype.

Specifications


  • Dilution Range: 1:100 - 1:200*

Package Inserts


IFU:
IFU included with product

SDS:
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Ordering Information

For research use only (RUO) in USA

0.1 mL concentrateAC-0331RUO
1 mL concentrateAC-0331RUOC

This product is not available in Canada

For research use only (RUO) in the EU

0.1 mL concentrateAC-0331RUO
1 mL concentrateAC-0331RUOC

For research use only (RUO) in Japan

0.1 mL concentrateAC-0331RUO
1 mL concentrateAC-0331RUOC

 

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