Lambda Light Chain Rabbit Polyclonal Antibody

Lambda Light Chain
Tonsil stained with anti-Lambda Light Chain

Lambda Light Chain Rabbit Polyclonal Antibody

Updated: 2017-05-24 08:46:09

Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two types of light chains designated as kappa and lambda. The gene rearrangement process that generates the immunoglobulin molecule results in either a productive kappa gene or a productive lambda gene. The mechanics of the rearrangement process normally produce approximately twice as many kappa-bearing cells as lambda. However this ratio loses during malignant transformation. The lambda light chain antibody labels lambda light chain expressing normal and neoplastic B lymphocytes and plasma cells. Other cells may also express lambda light chain due to nonspecific uptake of immunoglobulin. Individual B cells express either kappa or lambda light chains. Monoclonality is generally assumed to be evidence of a malignant proliferation. Paired with kappa, lambda light chain is useful in identifying monoclonality of lymphoid malignancies.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: tonsil, B-cell lymphoma
  • Dilution Range: 1:100-1:200*

Package Inserts


IFU:
IFU included with product

SDS:
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Ordering Information

For in vitro diagnostic (IVD) use in USA

1 mL concentrateAC-0068
0.1 mL concentrateAC-0068A

This product is not available in Canada

For in vitro diagnostic (IVD) use in Europe

1 mL concentrateAC-0068
0.1 mL concentrateAC-0068A

For research use only (RUO) in Japan

1 mL concentrateAC-0068
0.1 mL concentrateAC-0068A

 

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