BMI-1 (EP199) Rabbit Monoclonal Antibody

BMI-1
Melanoma stained with anti-BMI-1

BMI-1 (EP199) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

BMI-1 (B lymphoma Mo-MLV insertion region 1 homolog), a key component of the PRC1 complex, was identified initially as an oncogene that cooperates with c-myc in the generation of B-cell lymphoma. It functions as a transcriptional repressor involved in gene silencing and the malignant transformation and biologic aggressiveness of several human carcinomas. Overexpression of BMI-1 is correlated with tumor progression in a variety of malignancies, including B-cell non-Hodgkin lymphoma, esophageal squamous carcinoma, and cancers of the bladder, cervix, ovary and breast. In contrast, loss of BMI expression has been reported to be associated with decreased patient survival in melanoma.

Specifications


  • Dilution Range: 1:100 - 1:200*

Package Inserts


IFU:
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Ordering Information

For research use only (RUO) in USA

0.1 mL concentrateAC-0168RUO
1 mL concentrateAC-0168RUOC

This product is not available in Canada

For research use only (RUO) in the EU

0.1 mL concentrateAC-0168RUO
1 mL concentrateAC-0168RUOC

For research use only (RUO) in Japan

0.1 mL concentrateAC-0168RUO
1 mL concentrateAC-0168RUOC

 

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