Aurora B (EP136) Rabbit Monoclonal Antibody

Aurora B
Colon cancer stained with anti-Aurora B

Aurora B (EP136) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: tonsil, colon carcinoma
  • Dilution Range: 1:20*

Package Inserts


No SDS found.

Ordering Information

For in vitro diagnostic (IVD) use in USA

1 mL concentrateAC-0196
0.1 mL concentrateAC-0196A

This product is not available in Canada

For in vitro diagnostic (IVD) use in Europe

1 mL concentrateAC-0196
0.1 mL concentrateAC-0196A

For research use only (RUO) in Japan

1 mL concentrateAC-0196
0.1 mL concentrateAC-0196A

 

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