Epitomics Portfolio

Aurora B (EP136)

Rabbit Monoclonal


The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: tonsil, colon carcinoma
  • Isotype: IgG
  • Dilution Range: 1:20*

IFU


IFU included with product

SDS


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Last updated: 2015-09-11 10:38:21

Aurora B
Colon cancer stained with anti-Aurora B

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: tonsil, colon carcinoma
  • Isotype: IgG
  • Dilution Range: 1:20

IFU


IFU included with product

SDS


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Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate AC-0196A
1 ml, concentrate AC-0196

This product is not available in Canada

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate AC-0196A
1 ml, concentrate AC-0196

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate AC-0196A
1 ml, concentrate AC-0196

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: tonsil, colon carcinoma
  • Isotype: IgG
  • Dilution Range: 1:20*

IFU


IFU included with product

SDS


Download your SDS

Download
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