IgA (EP170) Rabbit Monoclonal Antibody

IgA
IgA (EP170) on tonsil.

IgA (EP170) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

Immunoglobulin A (IgA) plays a critical role in mucosal immunity. It is present in the mucosal secretions such as tears, saliva, colostrum, intestinal juice, vaginal fluid, and secretions from the prostate and respiratory epithelium, and represents a key first line of defense against invasion by inhaled and ingested pathogens at the vulnerable mucosal surfaces. It is also found in small amounts in blood. Because it is resistant to degradation by enzymes, secretory IgA can survive in harsh environments such as the digestive and respiratory tracts, to provide protection against microbes that multiply in body secretions. It is useful when identifying multiple myeloma and plasmacytomas.1-3

  1. Ansari NA, et al. Immunoglobulin heavy and light chain isotypes in multiple myeloma patients. Asian Pac J Cancer Prev. 2007; 8:593-6.
  2. Leong AS, et al. Manual of diagonostic antibodies for Immunohistology. London: Greenwich Medical Media Ltd. 1999. p 217-19.
  3. Shao H, et al. Nodal and extranodal plasmacytomas expressing immunoglobulin A: an indolent lymphoproliferative disorder with a low risk of clinical progression. Am J Surg Pathol. 2010; 34:1425-35.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate267R-14
0.5 mL concentrate267R-15
1 mL concentrate267R-16
1 mL predilute267R-17
7 mL predilute267R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate267R-14
0.5 mL concentrate267R-15
1 mL concentrate267R-16
1 mL predilute267R-17
7 mL predilute267R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate267R-14
0.5 mL concentrate267R-15
1 mL concentrate267R-16
1 mL predilute267R-17
7 mL predilute267R-18

For research use only (RUO) in Japan

0.1 mL concentrate267R-14-RUO
0.5 mL concentrate267R-15-RUO
1 mL concentrate267R-16-RUO
1 mL predilute267R-17-RUO
7 mL predilute267R-18-RUO

 

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