Cell Marque Portfolio

C4d (SP91)

Rabbit Monoclonal


Acute humoral rejection is mediated by antibodies to the donor endothelium that activate the classical complement pathway.1-3 This leads to a number of split products of complement proteins. C4d is a fragment of C 4 complement released during activation of the classic complement pathway by the antigen antibody complex.3 C4d deposits in peritubular capillaries and is regarded as an indirect sign of an antibody response.3,6 C4d can be a useful tool for indicating acute renal allograft rejection.1-6

Specialties: Anatomic Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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References


  1. Jianghua C, et al. Clin Transplant. 2005; 19:785-91.
  2. Kayler LK, et al. Transplantation. 2008; 85:813-20.
  3. Ranjan P, et al. Nephrol Dial Transplant. 2008; 23:1735-41.
  4. Nadasdy GM, et al. Hum Pathol. 2005; 36:1178-85.
  5. Seemayer CA, et al. Nephrol Dial Transplant. 2007; 22:568-76.
  6. Bouron-Dal Soglio D, et al. Hum Pathol. 2008; 39:1103-10.

Last updated: 2017-05-24 08:46:09

C4d
C4d (SP91) on acute rejected kidney.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

References


  1. Jianghua C, et al. Clin Transplant. 2005; 19:785-91.
  2. Kayler LK, et al. Transplantation. 2008; 85:813-20.
  3. Ranjan P, et al. Nephrol Dial Transplant. 2008; 23:1735-41.
  4. Nadasdy GM, et al. Hum Pathol. 2005; 36:1178-85.
  5. Seemayer CA, et al. Nephrol Dial Transplant. 2007; 22:568-76.
  6. Bouron-Dal Soglio D, et al. Hum Pathol. 2008; 39:1103-10.

Download an IFU

Select revision:


Download SDS


Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 404R-14
0.5 ml, concentrate 404R-15
1 ml, concentrate 404R-16
1 ml, predilute 404R-17
7 ml, predilute 404R-18
25 ml, predilute 404R-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 404R-14
0.5 ml, concentrate 404R-15
1 ml, concentrate 404R-16
1 ml, predilute 404R-17
7 ml, predilute 404R-18
25 ml, predilute 404R-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 404R-14
0.5 ml, concentrate 404R-15
1 ml, concentrate 404R-16
1 ml, predilute 404R-17
7 ml, predilute 404R-18
25 ml, predilute 404R-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 404R-14-RUO
0.5 ml, concentrate 404R-15-RUO
1 ml, concentrate 404R-16-RUO
1 ml, predilute 404R-17-RUO
7 ml, predilute 404R-18-RUO
25 ml, predilute 404R-10-RUO

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

Download SDS

References


  1. Jianghua C, et al. Clin Transplant. 2005; 19:785-91.
  2. Kayler LK, et al. Transplantation. 2008; 85:813-20.
  3. Ranjan P, et al. Nephrol Dial Transplant. 2008; 23:1735-41.
  4. Nadasdy GM, et al. Hum Pathol. 2005; 36:1178-85.
  5. Seemayer CA, et al. Nephrol Dial Transplant. 2007; 22:568-76.
  6. Bouron-Dal Soglio D, et al. Hum Pathol. 2008; 39:1103-10.
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