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C4d (SP91)

Rabbit Monoclonal


Acute humoral rejection is mediated by antibodies to the donor endothelium that activate the classical complement pathway.1-3 This leads to a number of split products of complement proteins. C4d is a fragment of C 4 complement released during activation of the classic complement pathway by the antigen antibody complex.3 C4d deposits in peritubular capillaries and is regarded as an indirect sign of an antibody response.3,6 C4d can be a useful tool for indicating acute renal allograft rejection.1-6

Specialties: Anatomic Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Package Inserts


IFU SDS

References


  1. Jianghua C, et al. Clin Transplant. 2005; 19:785-91.
  2. Kayler LK, et al. Transplantation. 2008; 85:813-20.
  3. Ranjan P, et al. Nephrol Dial Transplant. 2008; 23:1735-41.
  4. Nadasdy GM, et al. Hum Pathol. 2005; 36:1178-85.
  5. Seemayer CA, et al. Nephrol Dial Transplant. 2007; 22:568-76.
  6. Bouron-Dal Soglio D, et al. Hum Pathol. 2008; 39:1103-10.

Last updated: 2017-05-24 08:46:09

C4d
C4d (SP91) on acute rejected kidney.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

References


  1. Jianghua C, et al. Clin Transplant. 2005; 19:785-91.
  2. Kayler LK, et al. Transplantation. 2008; 85:813-20.
  3. Ranjan P, et al. Nephrol Dial Transplant. 2008; 23:1735-41.
  4. Nadasdy GM, et al. Hum Pathol. 2005; 36:1178-85.
  5. Seemayer CA, et al. Nephrol Dial Transplant. 2007; 22:568-76.
  6. Bouron-Dal Soglio D, et al. Hum Pathol. 2008; 39:1103-10.

Package Inserts

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute 404R-10
0.1 mL concentrate 404R-14
0.5 mL concentrate 404R-15
1 mL concentrate 404R-16
1 mL predilute 404R-17
7 mL predilute 404R-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute 404R-10
0.1 mL concentrate 404R-14
0.5 mL concentrate 404R-15
1 mL concentrate 404R-16
1 mL predilute 404R-17
7 mL predilute 404R-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute 404R-10
0.1 mL concentrate 404R-14
0.5 mL concentrate 404R-15
1 mL concentrate 404R-16
1 mL predilute 404R-17
7 mL predilute 404R-18

For research use only (RUO) in Japan

25 mL predilute 404R-10-RUO
0.1 mL concentrate 404R-14-RUO
0.5 mL concentrate 404R-15-RUO
1 mL concentrate 404R-16-RUO
1 mL predilute 404R-17-RUO
7 mL predilute 404R-18-RUO

 

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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References


  1. Jianghua C, et al. Clin Transplant. 2005; 19:785-91.
  2. Kayler LK, et al. Transplantation. 2008; 85:813-20.
  3. Ranjan P, et al. Nephrol Dial Transplant. 2008; 23:1735-41.
  4. Nadasdy GM, et al. Hum Pathol. 2005; 36:1178-85.
  5. Seemayer CA, et al. Nephrol Dial Transplant. 2007; 22:568-76.
  6. Bouron-Dal Soglio D, et al. Hum Pathol. 2008; 39:1103-10.
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