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C4d (SP91)

Rabbit Monoclonal


C4d is a stable split product remnant of classical complement activation which becomes covalently bound to endothelium and basement membrane after induction of the classical antibody-induced pathway. As an established marker of antibody-mediated acute renal allograft rejection (AR) and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be closely correlated with transplant kidney graft survival1-3. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of AR that may serve to warrant prompt and aggressive anti-rejection treatment1-6.

Specialties: Anatomic Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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Last updated: 2016-09-29 13:18:40

C4d
C4d (SP91) on acute rejected kidney.

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Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 404R-14
0.5 ml, concentrate 404R-15
1 ml, concentrate 404R-16
1 ml, predilute 404R-17
7 ml, predilute 404R-18
25 ml, predilute 404R-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 404R-14
0.5 ml, concentrate 404R-15
1 ml, concentrate 404R-16
1 ml, predilute 404R-17
7 ml, predilute 404R-18
25 ml, predilute 404R-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 404R-14
0.5 ml, concentrate 404R-15
1 ml, concentrate 404R-16
1 ml, predilute 404R-17
7 ml, predilute 404R-18
25 ml, predilute 404R-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 404R-14 (RUO)
0.5 ml, concentrate 404R-15 (RUO)
1 ml, concentrate 404R-16 (RUO)
1 ml, predilute 404R-17 (RUO)
7 ml, predilute 404R-18 (RUO)
25 ml, predilute 404R-10 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil, acute rejected kidney transplant
  • Isotype: IgG
  • Dilution Range: 1:50-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana OptiView
    OV/CC1(32min)/32min @ 37°C
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

Request More Information