Cell Marque Portfolio

MLH1 (G168-728)

Mouse Monoclonal


MLH1 is a mismatch repair protein that is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. Anti-MLH1 may be useful in identification of MLH1 protein in variety of normal and neoplastic tissues and identification of loss of MLH1 in tumors with MSI genotype.1-8 Anti-MLH1 is best utilized in an IHC panel that includes anti-MSH6, anti-MSH2, and anti-PMS2.

Specialties: Gastrointestinal (GI) Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon, colon carcinoma
  • Isotype: IgG2a
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

References


  1. Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-1406.
  2. Brueckl WM, et al. Anticancer Research. 2003; 23:1773-1778.
  3. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
  4. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-3637.
  5. Hoedema R, et al. The American Surgeon. 2003; 69:387-92.
  6. Christensen M, et al. Cancer. 2002; 95:2422-30.
  7. Wahlberg SS, et al. Cancer Research. 2002; 62:3485-3492.
  8. Lanza G, et al. Modern Pathology. 2002; 15: 741-749.

Last updated: 2017-05-24 08:46:09

MLH1
Nuclear staining by anti-MLH1 on colon tubular adenoma.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon, colon carcinoma
  • Isotype: IgG2a
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

References


  1. Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-1406.
  2. Brueckl WM, et al. Anticancer Research. 2003; 23:1773-1778.
  3. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
  4. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-3637.
  5. Hoedema R, et al. The American Surgeon. 2003; 69:387-92.
  6. Christensen M, et al. Cancer. 2002; 95:2422-30.
  7. Wahlberg SS, et al. Cancer Research. 2002; 62:3485-3492.
  8. Lanza G, et al. Modern Pathology. 2002; 15: 741-749.

Package Inserts

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Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 mL concentrate 285M-14
0.5 mL concentrate 285M-15
1 mL concentrate 285M-16
1 mL predilute 285M-17
7 mL predilute 285M-18
25 mL predilute 285M-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 mL concentrate 285M-14
0.5 mL concentrate 285M-15
1 mL concentrate 285M-16
1 mL predilute 285M-17
7 mL predilute 285M-18
25 mL predilute 285M-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 mL concentrate 285M-14
0.5 mL concentrate 285M-15
1 mL concentrate 285M-16
1 mL predilute 285M-17
7 mL predilute 285M-18
25 mL predilute 285M-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 mL concentrate 285M-14-RUO
0.5 mL concentrate 285M-15-RUO
1 mL concentrate 285M-16-RUO
1 mL predilute 285M-17-RUO
7 mL predilute 285M-18-RUO
25 mL predilute 285M-10-RUO

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon, colon carcinoma
  • Isotype: IgG2a
  • Dilution Range: 1:25-1:100*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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References


  1. Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-1406.
  2. Brueckl WM, et al. Anticancer Research. 2003; 23:1773-1778.
  3. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
  4. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-3637.
  5. Hoedema R, et al. The American Surgeon. 2003; 69:387-92.
  6. Christensen M, et al. Cancer. 2002; 95:2422-30.
  7. Wahlberg SS, et al. Cancer Research. 2002; 62:3485-3492.
  8. Lanza G, et al. Modern Pathology. 2002; 15: 741-749.
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