TROP2 (EP431) Rabbit Monoclonal Primary Antibody
Specialties: Anatomic Pathology Cytopathology
Trophoblast antigen 2 (TROP2) is a transmembrane glycoprotein that transduces intracellular calcium signals1. The overexpression of TROP2 has been linked to tumor progression due to its involvement in the regulation of multiple vital cell processes including migration, proliferation, and invasion2. TROP2 exhibits strong, diffuse staining in papillary thyroid carcinoma, while staining in other thyroid lesions, such as follicular thyroid adenomas and carcinomas, is limited to rare, focal, or scattered cells3,4. An increase in TROP2 expression has also been observed in colorectal carcinomas and ovarian serous carcinomas compared to non-neoplastic ovary and colon5.
- Ripani E, et al. Human TROP-2 is a tumor-associated calcium signal transducer. Int J Cancer. 1998;76(5):671-676
- Wu B, et al. Overexpression of TROP2 promotes proliferation and invasion of ovarian cancer cells. Exp Ther Med. 2017;14(3):1947-1952
- Bychkov A, et al. TROP-2 immunohistochemistry: a highly accurate method in the differential diagnosis of papillary thyroid carcinoma. Pathology. 2016;48(5):425-433
- Liu H, et al. The Potential Diagnostic Utility of TROP-2 in Thyroid Neoplasms. Appl Immunohistochem Mol Morphol. 2017;25(8):525-533
- Stephan LP, et al. Expression of Trop2 Cell Surface Glycoprotein in Normal and Tumor Tissues. J Histochem Cytochem. 2011;59(7):701-710
Specifications
- Reactivity: paraffin
- Control: Papillary thyroid carcinoma (Cytoplasmic, Membranous)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC46531000)
Have a different keycode?
Click Here
Learn how to obtain your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 465R-14 |
| 0.5 mL concentrate | 465R-15 |
| 1.0 mL concentrate | 465R-16 |
| 1.0 mL predilute ready-to-use | 465R-17 |
| 7.0 mL predilute ready-to-use | 465R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 465R-14 |
| 0.5 mL concentrate | 465R-15 |
| 1.0 mL concentrate | 465R-16 |
| 1.0 mL predilute ready-to-use | 465R-17 |
| 7.0 mL predilute ready-to-use | 465R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 465R-14 |
| 0.5 mL concentrate | 465R-15 |
| 1.0 mL concentrate | 465R-16 |
| 1.0 mL predilute ready-to-use | 465R-17 |
| 7.0 mL predilute ready-to-use | 465R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 465R-14-RUO |
| 1.0 mL concentrate (RUO) | 465R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 465R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 465R-18-RUO |
To request information on this product in additional countries, please click the button below.
