SF-1 (EP434) Rabbit Monoclonal Primary Antibody
Specialties: Anatomic Pathology Genitourinary (GU) Pathology
As both a nuclear receptor and nuclear transcription factor, Steroidogenic factor-1 (SF-1) serves as an important modulator of steroidogenesis.1,2 It has been demonstrated that SF-1 serves as a “master regulator” in varying facets of development and function in both reproductive and adrenal tissues.1 Immunohistochemical detection of SF-1 in testicular tissue may provide value for distinguishing sex-cord stromal tumors, including Leydig cell, Sertoli cell and granulosa cell neoplasms, from other tumors.2,3 In addition, SF-1 detection may have utility in distinguishing primary adrenal cortical lesions from their histologic mimics such as renal clear cell carcinoma.4
- El-Khairi, R et al. Steroidogenic Factor-1 and Human Disease. Seminars in Reproductive Medicine 2012 30(5): 374-381
- Sangoi AR et al. Evaluation of SF-1 Expression in Testicular Germ Cell Tumors: A Tissue Microarray Study of 127 cases. Applied Immunohistochemistry and Molecular Morphology 2013 21(4): 318-321
- Zhao, C et al. Identification of the Most Sensitive and Robust Immunohistochemical Markers in Different Categories of Ovarian Sex Cord-stromal Tumors. American Journal of Surgical Pathology 2009 33(3): 354-365
- Sangoi, AR et al. Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal carcinoma: a study of 248 cases. American Journal of Surgical Pathology 2011 35(5): 678-686
Specifications
- Reactivity: paraffin
- Control: Adrenocortical carcinoma (Nuclear); Testis (Nuclear); Granulosa cell tumor (Nuclear)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC46231000)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 462R-14 |
| 0.5 mL concentrate | 462R-15 |
| 1.0 mL concentrate | 462R-16 |
| 1.0 mL predilute ready-to-use | 462R-17 |
| 7.0 mL predilute ready-to-use | 462R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 462R-14 |
| 0.5 mL concentrate | 462R-15 |
| 1.0 mL concentrate | 462R-16 |
| 1.0 mL predilute ready-to-use | 462R-17 |
| 7.0 mL predilute ready-to-use | 462R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 462R-14 |
| 0.5 mL concentrate | 462R-15 |
| 1.0 mL concentrate | 462R-16 |
| 1.0 mL predilute ready-to-use | 462R-17 |
| 7.0 mL predilute ready-to-use | 462R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 462R-14-RUO |
| 1.0 mL concentrate (RUO) | 462R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 462R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 462R-18-RUO |
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