SF-1 (EP434) Rabbit Monoclonal Primary Antibody

SF-1

SF-1 (EP434) Rabbit Monoclonal Primary Antibody

Specialties: Anatomic Pathology Genitourinary (GU) Pathology

Updated: 2020-05-21 09:18:28

As both a nuclear receptor and nuclear transcription factor, Steroidogenic factor-1 (SF-1) serves as an important modulator of steroidogenesis.1,2 It has been demonstrated that SF-1 serves as a “master regulator” in varying facets of development and function in both reproductive and adrenal tissues.1 Immunohistochemical detection of SF-1 in testicular tissue may provide value for distinguishing sex-cord stromal tumors, including Leydig cell, Sertoli cell and granulosa cell neoplasms, from other tumors.2,3 In addition, SF-1 detection may have utility in distinguishing primary adrenal cortical lesions from their histologic mimics such as renal clear cell carcinoma.4

  1. El-Khairi, R et al. Steroidogenic Factor-1 and Human Disease. Seminars in Reproductive Medicine 2012 30(5): 374-381
  2. Sangoi AR et al. Evaluation of SF-1 Expression in Testicular Germ Cell Tumors: A Tissue Microarray Study of 127 cases. Applied Immunohistochemistry and Molecular Morphology 2013 21(4): 318-321
  3. Zhao, C et al. Identification of the Most Sensitive and Robust Immunohistochemical Markers in Different Categories of Ovarian Sex Cord-stromal Tumors. American Journal of Surgical Pathology 2009 33(3): 354-365
  4. Sangoi, AR et al. Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal carcinoma: a study of 248 cases. American Journal of Surgical Pathology 2011 35(5): 678-686

Specifications


  • Reactivity: paraffin
  • Control: Adrenocortical carcinoma (Nuclear); Testis (Nuclear); Granulosa cell tumor (Nuclear)
  • Dilution Range: 1:25-1:100 *

Package Inserts


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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate462R-14
0.5 mL concentrate462R-15
1.0 mL concentrate462R-16
1.0 mL predilute ready-to-use462R-17
7.0 mL predilute ready-to-use462R-18

For research use only (RUO) in Canada

0.1 mL concentrate (RUO)462R-14-RUO
1.0 mL concentrate (RUO)462R-16-RUO
1.0 mL predilute ready-to-use (RUO)462R-17-RUO
7.0 mL predilute ready-to-use (RUO)462R-18-RUO

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate462R-14
0.5 mL concentrate462R-15
1.0 mL concentrate462R-16
1.0 mL predilute ready-to-use462R-17
7.0 mL predilute ready-to-use462R-18

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)462R-14-RUO
1.0 mL concentrate (RUO)462R-16-RUO
1.0 mL predilute ready-to-use (RUO)462R-17-RUO
7.0 mL predilute ready-to-use (RUO)462R-18-RUO

 

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