TCL1 (EP105) Rabbit Monoclonal Primary Antibody

TCL1
TCL1 on lymph node with follicular lymphoma.

TCL1 (EP105) Rabbit Monoclonal Primary Antibody

Specialties: Hematopathology

Updated: 2019-05-29 14:50:17

T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene. TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell lymphoma.1-3 TCL1 binds to a novel site in the pleckstrin homology (PH) domain, resulting in activation and nuclear translocation of Akt by overexpressed TCL1 which may promote an anti-apoptotic response; this may normally serve to promote growth during development but may lead to malignancy when TCL1 is overexpressed.4  TCL1 is expressed in differentiated B-cells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. TCL1 is down-regulated in the latest stage of B-cell differentiation.5,6 TCL1 is overexpressed in Burkitt lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, and follicular lymphoma.2,7,8

  1. Takizawa J, et al., Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia. Jpn J Cancer Res. 1998; 89:712-8.
  2. Bichi R, et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci USA. 2002; 99:6955-60.
  3. Herling M, et al. TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. Leukemia. 2006; 20:280-5.
  4. Roos J, et al. Expression of TCL1 in hematologic disorders. Pathobiology. 2001; 69:59-66.
  5. Pekarsky Y, et al. The role of TCL1 in human T-cell leukemia. Oncogene. 2001; 20:5638-43.
  6. Pekarsky Y, et al. TCL1 as a model for lymphomagenesis. Hematol Oncol Clin North Am. 2004; 18:863-79.
  7. Rodig SJ, et al. Characteristic expression patterns of TCL1, CD38, and CD44 identify aggressive lymphomas harboring MYC translocation. Am J Surg Pathol. 2008; 32:113-22.
  8. Nakayama I, et al. Activation of the TCL1 protein in B cell lymphomas. Pathol Int. 2000; 50:191-9.

Specifications


  • Reactivity: paraffin
  • Control: Tonsil (Cytoplasmic, Nuclear); Follicular lymphoma (Nuclear)
  • Dilution Range: 1:100-1:200 *

Package Inserts


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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate357R-14
0.5 mL concentrate357R-15
1.0 mL concentrate357R-16
1.0 mL predilute ready-to-use357R-17
7.0 mL predilute ready-to-use357R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate357R-14
0.5 mL concentrate357R-15
1.0 mL concentrate357R-16
1.0 mL predilute ready-to-use357R-17
7.0 mL predilute ready-to-use357R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate357R-14
0.5 mL concentrate357R-15
1.0 mL concentrate357R-16
1.0 mL predilute ready-to-use357R-17
7.0 mL predilute ready-to-use357R-18

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)357R-14-RUO
0.5 mL concentrate (RUO)357R-15-RUO
1.0 mL concentrate (RUO)357R-16-RUO
1.0 mL predilute ready-to-use (RUO)357R-17-RUO
7.0 mL predilute ready-to-use (RUO)357R-18-RUO

 

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