Nanog (EP225) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology Genitourinary (GU) Pathology
Nanog is a transcription factor homeoprotein that is involved in maintaining embryonic stem cell pluripotency and self-renewal.1-3 Embryonic stem cells with a deleted Nanog gene lose pluripotency. Conversely, embryonic stem cells that are forced to differentiate will down-regulate Nanog expression.1-2 Nanog expression has been shown to be absent in normal adult organ tissues, but positive expression in undifferentiated germ cell tumors such as seminoma, dysgerminoma and embryonal carcinoma has been noted.1,2,4,5 Therefore, Nanog may be used as an aid in the determination of undifferentiated tumors of germ cell origin from non-germ cell tumors.4,5
- Mitsu K, et al. Cell. 2003; 113:631-42.
- Chambers I, et al. Cell. 2003; 113:643-55.
- Pan G, et al. Cell Research. 2007; 17:42-9.
- Hart AH, et al. Cancer. 2005; 104:2092-98.
- Chang MC, et al. Int J Gynecol Pathol. 2009; 28:347-55.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: seminoma
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC44331010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 443R-14 |
| 0.5 mL concentrate | 443R-15 |
| 1 mL concentrate | 443R-16 |
| 1 mL predilute | 443R-17 |
| 7 mL predilute | 443R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 443R-14 |
| 0.5 mL concentrate | 443R-15 |
| 1 mL concentrate | 443R-16 |
| 1 mL predilute | 443R-17 |
| 7 mL predilute | 443R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 443R-14 |
| 0.5 mL concentrate | 443R-15 |
| 1 mL concentrate | 443R-16 |
| 1 mL predilute | 443R-17 |
| 7 mL predilute | 443R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 443R-14-RUO |
| 0.5 mL concentrate | 443R-15-RUO |
| 1 mL concentrate | 443R-16-RUO |
| 1 mL predilute | 443R-17-RUO |
| 7 mL predilute | 443R-18-RUO |
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