CD11c (EP157) Rabbit Monoclonal Antibody
Specialties: Hematopathology
CD11c is an adhesion receptor of the leukocyte function-associated family of molecules. This cell surface antigen is normally expressed on granulocytes, monocytes, natural killer cells, macrophages, and small populations of T- and B-lymphocytes. Anti-CD11c detects a formalin-resistant epitope of CD11c expressed in hairy cell leukemia (HCL). HCL is a distinctive yet uncommon chronic B-cell lymphoproliferative disorder, predominantly involving the bone marrow and spleen. Besides being consistently expressed in HCL, CD11c is rarely detected in lymphomas; such as small lymphocytic lymphoma (SLL), and nodal and extranodal marginal zone lymphoma (MZL).1-3
- Johrens K, et al. Pathobiology. 2008; 75:252-256.
- Jones G, et al. Br J Hemaetol. 2012; 156:186-195.
- Marotta, G et al. Leuk Lymphoma. 2000; 37:145-9.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: hairy cell leukemia, spleen, tonsil
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC11131010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 111R-14 |
| 0.5 mL concentrate | 111R-15 |
| 1 mL concentrate | 111R-16 |
| 1 mL predilute | 111R-17 |
| 7 mL predilute | 111R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 111R-14 |
| 0.5 mL concentrate | 111R-15 |
| 1 mL concentrate | 111R-16 |
| 1 mL predilute | 111R-17 |
| 7 mL predilute | 111R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 111R-14 |
| 0.5 mL concentrate | 111R-15 |
| 1 mL concentrate | 111R-16 |
| 1 mL predilute | 111R-17 |
| 7 mL predilute | 111R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 111R-14-RUO |
| 0.5 mL concentrate | 111R-15-RUO |
| 1 mL concentrate | 111R-16-RUO |
| 1 mL predilute | 111R-17-RUO |
| 7 mL predilute | 111R-18-RUO |
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