Caveolin-1 (2297) Mouse Monoclonal Antibody
Specialties: Cytopathology Pulmonary Pathology
Caveolin-1 (CAV-1) is a cell membrane-associated structural component of flask-shaped plasma membrane invaginations termed caveolae.1 CAV-1 is expressed at different levels in different tissues, with the highest in adipocytes, endothelial cells, fibroblasts, alveolar type I pneumocytes, and mesothelial cells.1-2 Anti-Caveolin-1 immunoreactivity is seen in the vast majority of epithelioid mesotheliomas and Ewing sarcoma/PNET, whereas reactivity in lung adenocarcinomas is only occasionally seen and in a weak and focal pattern.2-3
- Cohen AW, et al. Role of caveolae and caveolins in health and disease. Physiol Rev. 2004; 84:1341-79.
- Amatya VJ, et al. Caveolin-1 is a novel Immunohistochemical marker to differentiate Epithelioid Mesothelioma from Lung Adenocarcinoma. Histopathology. 2009; 55:10-9.
- Llombart-Bosch A, et al. Histological heterogeneity of Ewing’s sarcoma/PNET: An immunohistochemical analysis of 415 genetically confirmed cases with clinical support. Virchows Arch. 2009; 455:397-411.
Specifications
- Reactivity: paraffin
- Visualization: membranous
- Control: mesothelioma, Ewing sarcoma
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 3.0 (CMC41221030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 412M-14 |
| 0.5 mL concentrate | 412M-15 |
| 1 mL concentrate | 412M-16 |
| 1 mL predilute | 412M-17 |
| 7 mL predilute | 412M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 412M-14 |
| 0.5 mL concentrate | 412M-15 |
| 1 mL concentrate | 412M-16 |
| 1 mL predilute | 412M-17 |
| 7 mL predilute | 412M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 412M-14 |
| 0.5 mL concentrate | 412M-15 |
| 1 mL concentrate | 412M-16 |
| 1 mL predilute | 412M-17 |
| 7 mL predilute | 412M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 412M-14-RUO |
| 0.5 mL concentrate | 412M-15-RUO |
| 1 mL concentrate | 412M-16-RUO |
| 1 mL predilute | 412M-17-RUO |
| 7 mL predilute | 412M-18-RUO |
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