MyoD1 (EP212) Rabbit Monoclonal Primary Antibody

MyoD1
Rhabdomyosarcoma cells are labeled in a nuclear pattern by anti-MyoD1.

MyoD1 (EP212) Rabbit Monoclonal Primary Antibody

Specialties: Pediatric Pathology Soft Tissue Pathology

Updated: 2019-08-26 16:14:36

Rhabdomyosarcomas (RMS) are the most frequent malignant soft tissue neoplasms of childhood.1 While better differentiated RMS have cross-striations or rhabdomyoblasts that allow for a confident morphologic diagnosis, less differentiated RMS resemble other small blue round-cell tumors.1 MyoD1, one of the MyoD family of myogenic helix-loop-helix transcription factors, combined with myogenin, plays a role in coordinating the myogenic differentiation pathway from the determination of mesodermal precursors into myoblasts, the differentiation of myoblasts into myotubes, and finally the maturation of myotubes into skeletal myofibers.2 Normal mature skeletal muscle does not express MyoD1 protein.1-2 MyoD1 is expressed in myoblasts before differentiation while myogenin has post-differentiation functions.2 Anti-MyoD1 immunostaining identifies cells committed to myogenesis in their earliest phase, thus, it is a better biomarker for less differentiated RMS.2 Studies suggest, anti-MyoD1 may be used together with anti-myogenin and anti-desmin as a panel of markers since any RMS is virtually never negative for all three markers simultaneously.1-2

  1. Morotti RA, et al. An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experience. Am J Surg Pathol. 2006; 30:962-968.
  2. Sebire NJ, et al. Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas. J. Clin. Pathol. 2003; 56:412-416.

Specifications


  • Reactivity: paraffin
  • Control: Rhabdomyosarcoma (Nuclear)
  • Dilution Range: 1:25-1:100 *

Package Inserts


IFU SDS
Learn how to obtain your SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate386R-14
0.5 mL concentrate386R-15
1.0 mL concentrate386R-16
1.0 mL predilute ready-to-use386R-17
7.0 mL predilute ready-to-use386R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate386R-14
0.5 mL concentrate386R-15
1.0 mL concentrate386R-16
1.0 mL predilute ready-to-use386R-17
7.0 mL predilute ready-to-use386R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate386R-14
0.5 mL concentrate386R-15
1.0 mL concentrate386R-16
1.0 mL predilute ready-to-use386R-17
7.0 mL predilute ready-to-use386R-18

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)386R-14-RUO
0.5 mL concentrate (RUO)386R-15-RUO
1.0 mL concentrate (RUO)386R-16-RUO
1.0 mL predilute ready-to-use (RUO)386R-17-RUO
7.0 mL predilute ready-to-use (RUO)386R-18-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information