GLUT1 Rabbit Polyclonal Antibody

GLUT1
GLUT1 is strongly expressed in the cytoplasm and membrane of colorectal carcinoma cells.

GLUT1 Rabbit Polyclonal Antibody

Specialties: Cytopathology Pulmonary Pathology

Updated: 2018-01-31 13:34:38

Glucose transporter type I (GLUT1), a prototype member of the GLUT superfamily, is a membrane-associated, erythrocyte glucose transport protein. It is a major glucose transporter in the mammalian blood-brain barrier, and also mediates glucose transport in endothelial cells of the vasculature, adipose tissue, and cardiac muscle. GLUT1 is detectable in many human tissues including those of colon, lung, stomach, and breast. GLUT1 is overexpressed in malignant cells and in a variety of tumors that include mesothelioma and  colon carcinoma.  Immunohistochemical detection of GLUT1 has been shown to discriminate between reactive mesothelium and malignant mesothelioma in more than one study.1,2  Anti-GLUT1 is also useful in distinguishing benign endometrial hyperplasia from atypical endometrial hyperplasia and adenocarcinoma. GLUT1 expression has been shown to be associated with increased malignant potential and invasiveness.3,4

  1. Kato Y, et al. Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. Mod Pathol. 2006; 20:215-20.
  2. Afify A, et al. Diagnostic utility of GLUT-1 expression in the cytologic evaluation of serous fluids. Acta Cytol. 2005; 49:621-6.
  3. Parente P, et al. Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions. J Exp Clin Cancer Res. 2008; 27:34.
  4. Zimmerman RL, et al. Diagnostic utility of Glut-1 and CA 15-3 in discriminating adenocarcinoma from hepatocellular carcinoma in liver tumors biopsied by fine-needle aspiration. Cancer. 2002; 96:53-7.

Specifications


  • Reactivity: paraffin
  • Control: Colorectal carcinoma (Membranous); Mesothelioma (Membranous)
  • Dilution Range: 1:50-1:200 *

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate355A-14
0.5 mL concentrate355A-15
1.0 mL concentrate355A-16
1.0 mL predilute ready-to-use355A-17
7.0 mL predilute ready-to-use355A-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate355A-14
0.5 mL concentrate355A-15
1.0 mL concentrate355A-16
1.0 mL predilute ready-to-use355A-17
7.0 mL predilute ready-to-use355A-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate355A-14
0.5 mL concentrate355A-15
1.0 mL concentrate355A-16
1.0 mL predilute ready-to-use355A-17
7.0 mL predilute ready-to-use355A-18

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)355A-14-RUO
0.5 mL concentrate (RUO)355A-15-RUO
1.0 mL concentrate (RUO)355A-16-RUO
1.0 mL predilute ready-to-use (RUO)355A-17-RUO
7.0 mL predilute ready-to-use (RUO)355A-18-RUO

 

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