Oct-2 (MRQ-2) Mouse Monoclonal Antibody

Oct-2
Lymphoma cells are expressed in diffuse large B-cell lymphoma in a nuclear reaction by Oct-2 antibody.

Oct-2 (MRQ-2) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2018-01-31 11:34:45

Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. These are involved in proliferation and differentiation and, despite the scarce evidence for Oct-2 expression in T cells, it has been shown that this factor participates in transcriptional regulation during T-cell activation. Oct-2 activity is dependent on phosphorylation and alternatitive splicing.Various lymphomas are also positive for this marker including the following: B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and classic Hodgkin lymphoma.1-3

  1. Browne P, et al. The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol. 2003; 120:767-77.
  2. García-Cosío M, et al. Analysis of transcription factor OCT.1, OCT.2 and BOB.1 expres­sion using tissue arrays in classical Hodgkin’s lymphoma. Mod Pathol. 2004; 17:1531-8.
  3. Gibson SE, et al. Expression of the B cell-associ­ated transcription factors PAX5, OCT-2, and BOB.1 in acute myeloid leu­kemia: associations with B-cell antigen expression and myelomonocytic maturation. Am J Clin Pathol. 2006; 126:916-24.

Specifications


  • Reactivity: paraffin
  • Control: Tonsil (Nuclear); Lymph node (Nuclear)
  • Dilution Range: 1:25-1:100 *

Package Inserts


IFU SDS
Learn how to obtain your SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate308M-14
0.5 mL concentrate308M-15
1.0 mL concentrate308M-16
1.0 mL predilute ready-to-use308M-17
7.0 mL predilute ready-to-use308M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate308M-14
0.5 mL concentrate308M-15
1.0 mL concentrate308M-16
1.0 mL predilute ready-to-use308M-17
7.0 mL predilute ready-to-use308M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate308M-14
0.5 mL concentrate308M-15
1.0 mL concentrate308M-16
1.0 mL predilute ready-to-use308M-17
7.0 mL predilute ready-to-use308M-18

For research use only (RUO) in Japan

0.1 mL concentrate (RUO)308M-14-RUO
0.5 mL concentrate (RUO)308M-15-RUO
1.0 mL concentrate (RUO)308M-16-RUO
1.0 mL predilute ready-to-use (RUO)308M-17-RUO
7.0 mL predilute ready-to-use (RUO)308M-18-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information