Abundant cytoplasmic labelling on seminoma by podoplanin antibody.
Podoplanin (D2-40) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Updated: 2022-07-05 12:34:58
Podoplanin is a transmembrane mucoprotein (38 kD) recognized by the D2-40 monoclonal antibody. Podoplanin is selectively expressed in normal and malignant lymphatic endothelium, including Kaposi’s sarcomas. Podoplanin has also been shown to be expressed in epithelioid mesotheliomas and seminomas.1-9
- Ordóñez NG. Podoplanin: a novel diagnostic immunohistochemical marker. Adv Anat Pathol. 2006; 13:83-8.
- Ordóñez N. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol. 2005; 36:372-80.
- Niakosari F, et al. Detection of lymphatic invasion in primary melanoma with monoclonal antibody D2-40: a new selective immunohistochemical marker of lymphatic endothelium. Arch Dermatol. 2005; 141:440-4.
- Galambos C, et al. Identification of lymphatic endothelium in pediatric vascular tumors and malformations. Pediatr Dev Pathol. 2005; 8:181-9.
- Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology. 2005; 46:396-402.
- Chu AY, et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol. 2005; 18:105-10.
- Franke FE, et al. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol. 2004; 31:362-7.
- Fogt F, et al. Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep. 2004; 11:47-50.
- Kahn HJ, et al. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol. 2002; 15:434-40.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Cytoplasmic, Membranous)
- Dilution Range: 1:20-1:100 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC32221060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 322M-10 |
| 0.1 mL concentrate | 322M-14 |
| 0.5 mL concentrate | 322M-15 |
| 1.0 mL concentrate | 322M-16 |
| 1.0 mL predilute ready-to-use | 322M-17 |
| 7.0 mL predilute ready-to-use | 322M-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 322M-10 |
| 0.1 mL concentrate | 322M-14 |
| 0.5 mL concentrate | 322M-15 |
| 1.0 mL concentrate | 322M-16 |
| 1.0 mL predilute ready-to-use | 322M-17 |
| 7.0 mL predilute ready-to-use | 322M-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 322M-10 |
| 0.1 mL concentrate | 322M-14 |
| 0.5 mL concentrate | 322M-15 |
| 1.0 mL concentrate | 322M-16 |
| 1.0 mL predilute ready-to-use | 322M-17 |
| 7.0 mL predilute ready-to-use | 322M-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 322M-10-RUO |
| 0.1 mL concentrate (RUO) | 322M-14-RUO |
| 0.5 mL concentrate (RUO) | 322M-15-RUO |
| 1.0 mL concentrate (RUO) | 322M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 322M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 322M-18-RUO |
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