Epitomics Portfolio

4E-BP1 (EP352)

Rabbit Monoclonal


The eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), also known as eIF4E-BP1, is a translation repressor inhibiting protein synthesis that sequester the mRNA cap-binding protein eIF4E. The Akt/mTOR/4E-BP1 pathway is considered to be a central regulator of protein synthesis.

This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Over expression of total and phosphorylated 4E-BP1 has been associated with tumor progression in carcinomas of the breast, ovary, prostate and liver.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: Colon, colon carcinoma
  • Isotype: IgG
  • Dilution Range: 1:100 - 1:200*

IFU


IFU included with product

SDS


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Last updated: 2017-05-24 08:46:09

4E-BP1
Breast carcinoma stained with anti-human 4E-BP1

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: Colon, colon carcinoma
  • Isotype: IgG
  • Dilution Range: 1:100 - 1:200

IFU


IFU included with product

SDS


Download your SDS

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Ordering Information

For research use only (RUO) in USA

DescriptionCat. No.
0.1 mL concentrate AC-0325RUO
1 mL concentrate AC-0325RUOC

This product is not available in Canada

For research use only (RUO) in the EU

DescriptionCat. No.
0.1 mL concentrate AC-0325RUO
1 mL concentrate AC-0325RUOC

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 mL concentrate AC-0325RUO
1 mL concentrate AC-0325RUOC

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: Colon, colon carcinoma
  • Isotype: IgG
  • Dilution Range: 1:100 - 1:200*

IFU


IFU included with product

SDS


Download your SDS

Download
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