Paxillin (EP89) Rabbit Monoclonal Antibody

Paxillin
Tonsil stained with anti-Paxillin

Paxillin (EP89) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

Paxillin is a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). It is a multidomain protein. The C-terminal region of paxillin contains four LIM domains that target paxillin to focal adhesions, presumably through a direct association with the cytoplasmic tail of beta-integrin. The N-terminus of paxillin controls most of its signaling activity. The proteins that bind to paxillin are diverse and include protein tyrosine kinases, such as Src and FAK, structural proteins, such as vinculin and actopaxin, and regulators of actin organization, such as COOL/PIX and PKL/GIT. Paxillin is widely expressed in epithelial cells of various tissues, neuronal cells and mesenchymal derived cells. An antibody to Paxillin is helpful in differentiating between renal cell carcinoma (Paxillin negative) and chromophobe renal cell carcinoma or renal oncocytoma (Paxillin positive), which are rare renal tumors originating from the intercalated cells of collecting ducts. Paxillin has been reported to be involved in tumor invasion and metastasis. Its expression in lung and liver cancers has been correlated with advanced tumor stage and metastasis.

Specifications


  • Dilution Range: 1:100 - 1:200*

Package Inserts


IFU:
IFU included with product

SDS:
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Ordering Information

For research use only (RUO) in USA

0.1 mL concentrateAC-0096RUO
1 mL concentrateAC-0096RUOC

This product is not available in Canada

For research use only (RUO) in the EU

0.1 mL concentrateAC-0096RUO
1 mL concentrateAC-0096RUOC

For research use only (RUO) in Japan

0.1 mL concentrateAC-0096RUO
1 mL concentrateAC-0096RUOC

 

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