MRP8 / S100A8 (EP90) Rabbit Monoclonal Antibody

MRP8 / S100A8
Spleen stained with anti-MRP8 / S100A8

MRP8 / S100A8 (EP90) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

Myeloid Related Protein 8 (MRP8), also known as S100A8, is a calcium binding protein that belongs to the S100 family. By a Ca2+ dependent manner, S100A8/A9 forms Calprotectin, a heterodimeric inflammatory mediator of inflammation found in the cytoplasm of neutrophils and expressed on the membrane of monocytes. S100A8 is expressed during myeloid differentiation and chronic inflammations, and it is expressed constitutively or induced in epithelial cells during dermatose. MRP8 is expressed in cells with myeloid origin, including granulocytes, monocytes and macrophages, and it is observed in blood granulocytes and monocytes. It is also expressed in infiltrate macrophages during inflammatory reactions, but not in normal tissue macrophages. MRP8 also reacts with activated microglial cells in human cerebral malaria. In tumors, positive staining of MRP8 has been observed in various cancers including pancreatic cancer, and it has been linked to inflammation-associated cancers.

Specifications


  • Dilution Range: 1:100 - 1:200*

Package Inserts


IFU:
IFU included with product

SDS:
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Ordering Information

For research use only (RUO) in USA

0.1 mL concentrateAC-0097RUO
1 mL concentrateAC-0097RUOC

This product is not available in Canada

For research use only (RUO) in the EU

0.1 mL concentrateAC-0097RUO
1 mL concentrateAC-0097RUOC

For research use only (RUO) in Japan

0.1 mL concentrateAC-0097RUO
1 mL concentrateAC-0097RUOC

 

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