BOB.1 (EP114) Rabbit Monoclonal Antibody

BOB.1
Tonsil stained with anti-BOB.1

BOB.1 (EP114) Rabbit Monoclonal Antibody

Updated: 2017-05-24 08:46:09

BOB.1, also know as B-cell-specific coactivator OBF-1 or OCA-B, is a lymphoid-specific transcriptional coactivator that interacts with the transcription factors Oct-1 and Oct-2. BOB.1 has been shown to be critical for the development of a normal immune response, where it mediates octamer-dependent transcriptional activity in B lymphocytes. It is also critically involved in the formation of germinal centers in secondary lymphoid organs. BOB.1 levels have been observed to be massively upregulated in germinal center B cells, as compared with resting B cells. The BOB.1 antibody labels B lymphocytes and plasma cells. It is expressed in various B-cell derived lymphomas and Hodgkin's lymphomas (HL). The expression of BOB.1 is high in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), but low in classic HL.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: tonsil, B-cell lymphoma
  • Dilution Range: 1:20*

Package Inserts


IFU:
IFU included with product

SDS:
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Ordering Information

For in vitro diagnostic (IVD) use in USA

1 mL concentrateAC-0114
0.1 mL concentrateAC-0114A

This product is not available in Canada

For in vitro diagnostic (IVD) use in Europe

1 mL concentrateAC-0114
0.1 mL concentrateAC-0114A

For research use only (RUO) in Japan

1 mL concentrateAC-0114
0.1 mL concentrateAC-0114A

 

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