Cytokeratin (35betaH11) Mouse Monoclonal Antibody

Cytokeratin
Cytokeratin 35betaH11 antibody diffusely and strongly illustrates the neoplastic cells of breast invasive ductal carcinoma in a cytoplasmic pattern.

Cytokeratin (35betaH11) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Cytokeratin 8, a member of the Type II family of cytokeratins, is typically expressed in simple epithelium. The dimerization of cytokeratin 8 with cytokeratin 18 (labeled by 35betaH11) in the cytoplasm of simple epithelial cells allows for the formation of an intermediate filament cytoskeletal framework.  This structure plays a role in the maintenance of cellular structural integrity and also functions in promoting signal transduction and cellular differentiation processes.1 Additionally, the presence of cytokeratin 8 has been detected in neoplastic epithelia, including glandular epithelium that can be found in prostate carcinoma.2 Positive immunoreactivity with anti-cytokeratin 8 is a useful indicator for the identification of normal and neoplastic epithelial tissues.2,3

  1. Moll R, et al. The human keratins: biology and pathology. Histochem Cell Biol. 2008; 129:705-33.
  2. Ljung G, et al. Characterization of residual tumor cells following radical radiation therapy for prostatic adenocarcinoma; immunohistochemical expression of prostate-specific antigen, prostatic acid phosphatase, and cytokeratin 8. Prostate. 1997; 31:91-7.
  3. Murata T, et al. The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma. Pathol Res Pract. 1993; 189:888-93.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: prostate
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate335M-94
0.5 mL concentrate335M-95
1 mL concentrate335M-96
1 mL predilute335M-97
7 mL predilute335M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate335M-94
0.5 mL concentrate335M-95
1 mL concentrate335M-96
1 mL predilute335M-97
7 mL predilute335M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate335M-94
0.5 mL concentrate335M-95
1 mL concentrate335M-96
1 mL predilute335M-97
7 mL predilute335M-98

For research use only (RUO) in Japan

0.1 mL concentrate335M-94-RUO
0.5 mL concentrate335M-95-RUO
1 mL concentrate335M-96-RUO
1 mL predilute335M-97-RUO
7 mL predilute335M-98-RUO

 

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