Cell Marque Portfolio

CD138/syndecan-1 (B-A38)

Mouse Monoclonal


CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.1 ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-associated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL.3,7 Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers.5 Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.4,6 CD138 is also expressed in epithelial cells.6

Specialties: Hematopathology

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Isotype: IgG1
  • Dilution Range: 1:25-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Chilosi M, et al. Mod Pathol. 1999; 12:1101-6.
  2. Sebestyén A, et al. Br J Haematol. 1999; 104:412-9.
  3. Delsol G, et al. WHO Press, Geneva, Switzerland. 254.
  4. Bayer-Garner IB, et al. Mod Pathol. 2001; 14:1052-8.
  5. Said J, et al. WHO Press, Geneva, Switzerland. 261.
  6. O’Connell FP, et al. Am J Clin Pathol. 2004; 121:254-63.
  7. Colomo L, et al. Am J Surg Pathol. 2004; 28:736-47.

Literature

Last updated: 2017-05-24 08:46:09

CD138/syndecan-1
CD138 antibody stains plasma cells in a strong cytoplasmic pattern.

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Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Isotype: IgG1
  • Dilution Range: 1:25-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

References


  1. Chilosi M, et al. Mod Pathol. 1999; 12:1101-6.
  2. Sebestyén A, et al. Br J Haematol. 1999; 104:412-9.
  3. Delsol G, et al. WHO Press, Geneva, Switzerland. 254.
  4. Bayer-Garner IB, et al. Mod Pathol. 2001; 14:1052-8.
  5. Said J, et al. WHO Press, Geneva, Switzerland. 261.
  6. O’Connell FP, et al. Am J Clin Pathol. 2004; 121:254-63.
  7. Colomo L, et al. Am J Surg Pathol. 2004; 28:736-47.

Package Inserts

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Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate 138M-14
0.5 mL concentrate 138M-15
1 mL concentrate 138M-16
1 mL predilute 138M-17
7 mL predilute 138M-18
25 mL predilute 138M-10

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate 138M-14
0.5 mL concentrate 138M-15
1 mL concentrate 138M-16
1 mL predilute 138M-17
7 mL predilute 138M-18
25 mL predilute 138M-10

For in vitro diagnostic (IVD) use in the EU

0.1 mL concentrate 138M-14
0.5 mL concentrate 138M-15
1 mL concentrate 138M-16
1 mL predilute 138M-17
7 mL predilute 138M-18
25 mL predilute 138M-10

For research use only (RUO) in Japan

0.1 mL concentrate 138M-14-RUO
0.5 mL concentrate 138M-15-RUO
1 mL concentrate 138M-16-RUO
1 mL predilute 138M-17-RUO
7 mL predilute 138M-18-RUO
25 mL predilute 138M-10-RUO

Literature

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Isotype: IgG1
  • Dilution Range: 1:25-1:200*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1M/16min @ 37°C

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References


  1. Chilosi M, et al. Mod Pathol. 1999; 12:1101-6.
  2. Sebestyén A, et al. Br J Haematol. 1999; 104:412-9.
  3. Delsol G, et al. WHO Press, Geneva, Switzerland. 254.
  4. Bayer-Garner IB, et al. Mod Pathol. 2001; 14:1052-8.
  5. Said J, et al. WHO Press, Geneva, Switzerland. 261.
  6. O’Connell FP, et al. Am J Clin Pathol. 2004; 121:254-63.
  7. Colomo L, et al. Am J Surg Pathol. 2004; 28:736-47.
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