CD138/syndecan-1 (B-A38) Mouse Monoclonal Antibody

CD138/syndecan-1
CD138 antibody stains plasma cells in a strong cytoplasmic pattern.

CD138/syndecan-1 (B-A38) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towards plasma cells.1,2 It can be used to differentiate lymphoplasmacytic lymphoma from marginal zone lymphoma.1 ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-associated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL.3,7 Anti-CD138 is immunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cells lack the expression of B-cell markers.5 Anti-CD138 is a good marker to identify and enumerate plasma cells, benign, reactive, or malignant, in bone marrow biopsy specimens.4,6 CD138 is also expressed in epithelial cells.6

  1. Chilosi M, et al. Mod Pathol. 1999; 12:1101-6.
  2. Sebestyén A, et al. Br J Haematol. 1999; 104:412-9.
  3. Delsol G, et al. WHO Press, Geneva, Switzerland. 254.
  4. Bayer-Garner IB, et al. Mod Pathol. 2001; 14:1052-8.
  5. Said J, et al. WHO Press, Geneva, Switzerland. 261.
  6. O’Connell FP, et al. Am J Clin Pathol. 2004; 121:254-63.
  7. Colomo L, et al. Am J Surg Pathol. 2004; 28:736-47.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Dilution Range: 1:25-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute138M-10
0.1 mL concentrate138M-14
0.5 mL concentrate138M-15
1 mL concentrate138M-16
1 mL predilute138M-17
7 mL predilute138M-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute138M-10
0.1 mL concentrate138M-14
0.5 mL concentrate138M-15
1 mL concentrate138M-16
1 mL predilute138M-17
7 mL predilute138M-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute138M-10
0.1 mL concentrate138M-14
0.5 mL concentrate138M-15
1 mL concentrate138M-16
1 mL predilute138M-17
7 mL predilute138M-18

For research use only (RUO) in Japan

25 mL predilute138M-10-RUO
0.1 mL concentrate138M-14-RUO
0.5 mL concentrate138M-15-RUO
1 mL concentrate138M-16-RUO
1 mL predilute138M-17-RUO
7 mL predilute138M-18-RUO

 

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Literature

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