CD56 (123C3.D5) Mouse Monoclonal Antibody

CD56
Lung neuroendocrine carcinoma strongly expresses CD56 protein in the cytoplasm of the neoplastic cells.

CD56 (123C3.D5) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilic binding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins.1-3 CD56 is involved in cell–cell adhesion of neural cells during embryogenesis and is expressed on most neuroectodermally derived tissues.1-3 In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in most NK cell neoplasms, certain subtypes of T-cell lymphoma and in some plasma cell neoplasms.4

  1. Walmod PS, et al. Zippers make signals: NCAM-mediated molecular interactions and signal transduction. Neurochem Res. 2004; 29:2015-35.
  2. Skog MS, et al. Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells. Stem Cell Res Ther. 2016; 7:113.
  3. Cohavy O, et al. CD56 marks an effector T cell subset in the human intestine. J Immunol. 2007; 178:5524-32.
  4. WHO Classification of tumors of Haematopoietic and Lymphoid Tissue. 4th Edition. 2008.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: neuroblastoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate156M-84
0.5 mL concentrate156M-85
1 mL concentrate156M-86
1 mL predilute156M-87
7 mL predilute156M-88

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate156M-84
0.5 mL concentrate156M-85
1 mL concentrate156M-86
1 mL predilute156M-87
7 mL predilute156M-88

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate156M-84
0.5 mL concentrate156M-85
1 mL concentrate156M-86
1 mL predilute156M-87
7 mL predilute156M-88

For research use only (RUO) in Japan

0.1 mL concentrate156M-84-RUO
0.5 mL concentrate156M-85-RUO
1 mL concentrate156M-86-RUO
1 mL predilute156M-87-RUO
7 mL predilute156M-88-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information