CD56 (123C3.D5) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilic binding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins.1-3 CD56 is involved in cell–cell adhesion of neural cells during embryogenesis and is expressed on most neuroectodermally derived tissues.1-3 In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in most NK cell neoplasms, certain subtypes of T-cell lymphoma and in some plasma cell neoplasms.4
- Walmod PS, et al. Zippers make signals: NCAM-mediated molecular interactions and signal transduction. Neurochem Res. 2004; 29:2015-35.
- Skog MS, et al. Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells. Stem Cell Res Ther. 2016; 7:113.
- Cohavy O, et al. CD56 marks an effector T cell subset in the human intestine. J Immunol. 2007; 178:5524-32.
- WHO Classification of tumors of Haematopoietic and Lymphoid Tissue. 4th Edition. 2008.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, membranous
- Control: neuroblastoma
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC15628040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 156M-84 |
| 0.5 mL concentrate | 156M-85 |
| 1 mL concentrate | 156M-86 |
| 1 mL predilute | 156M-87 |
| 7 mL predilute | 156M-88 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 156M-84 |
| 0.5 mL concentrate | 156M-85 |
| 1 mL concentrate | 156M-86 |
| 1 mL predilute | 156M-87 |
| 7 mL predilute | 156M-88 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 156M-84 |
| 0.5 mL concentrate | 156M-85 |
| 1 mL concentrate | 156M-86 |
| 1 mL predilute | 156M-87 |
| 7 mL predilute | 156M-88 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 156M-84-RUO |
| 0.5 mL concentrate | 156M-85-RUO |
| 1 mL concentrate | 156M-86-RUO |
| 1 mL predilute | 156M-87-RUO |
| 7 mL predilute | 156M-88-RUO |
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