CD15 (MMA) Mouse Monoclonal Antibody

CD15
CD15 (MMA) on lymph node, classic Hodgkin lymphoma.

CD15 (MMA) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD15 is a carbohydrate antigen with the common trisaccharide structure 3-fucosyl-N-acetyl-lactosamine, also known as Lewis x (Lex) or stage-specific embryonic antigen 1 (SSEA-1).1-3 CD15 is expressed in myeloid cells and mediates neutrophil adhesion to dendritic cells.2-3  CD15 is also expressed in Reed-Sternberg cells and is thus a useful marker for identifying Hodgkin’s lymphoma.1   

  1. Pellegrini W, et al. MMA monoclonal antibody is a superior anti-CD15 reagent for the diagnosis of classical Hodgkin's lymphoma. Haematologica. 2007; 92:708-9.
  2. Stocks SC, et al. Expression of the CD15 differentiation antigen (3-fucosyl-N-acetyl-lactosamine, LeX) on putative neutrophil adhesion molecules CR3 and NCA-160. Biochem J. 1990; 268: 275–80.
  3. Gadhoum SZ, et al. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol. 2008; 4:751-7.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: Hodgkin's lymphoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate115M-14
0.5 mL concentrate115M-15
1 mL concentrate115M-16
1 mL predilute115M-17
7 mL predilute115M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate115M-14
0.5 mL concentrate115M-15
1 mL concentrate115M-16
1 mL predilute115M-17
7 mL predilute115M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate115M-14
0.5 mL concentrate115M-15
1 mL concentrate115M-16
1 mL predilute115M-17
7 mL predilute115M-18

For research use only (RUO) in Japan

0.1 mL concentrate115M-14-RUO
0.5 mL concentrate115M-15-RUO
1 mL concentrate115M-16-RUO
1 mL predilute115M-17-RUO
7 mL predilute115M-18-RUO

 

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