CDK4 (DCS-31) Mouse Monoclonal Antibody
Specialties: Soft Tissue Pathology
Well-differentiated liposarcoma is a malignant, non-metastasizing tumor that can present with similar histological characteristics as benign lipoma lesions and has a higher recurrence rate. The CDK4 protein is frequently overexpressed in well-differentiated liposarcoma due to gene amplification of the 12q13-15 chromosomal region that harbors the CDK4 gene, but amplification and subsequent overexpression is rarely observed in lipomas. Due to CDK4 protein expression differences between these lesions, anti-CDK4 antibody can be used in an immunohistochemistry panel as an aid in the differential diagnosis between well-differentiated liposarcoma and lipoma.1,2,3
- Thway K, et al. Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. Am J Surg Pathol. 2012; 36(3):462-9.
- Aleixo PB, et al. Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol. 2009; 62(12):1127-35.
- Binh MBN, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: A comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005; 29(10):1340-7.
Specifications
- Reactivity: paraffin
- Control: Well-differentiated liposarcoma (Nuclear); Dedifferentiated liposarcoma (Nuclear)
- Dilution Range: 1:25-1:50 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC47829000)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 478M-94 |
| 0.5 mL concentrate | 478M-95 |
| 1.0 mL concentrate | 478M-96 |
| 1.0 mL predilute ready-to-use | 478M-97 |
| 7.0 mL predilute ready-to-use | 478M-98 |
For research use only (RUO) in Canada
| 0.1 mL concentrate (RUO) | 478M-94-RUO |
| 1.0 mL concentrate (RUO) | 478M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 478M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 478M-98-RUO |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 478M-94 |
| 0.5 mL concentrate | 478M-95 |
| 1.0 mL concentrate | 478M-96 |
| 1.0 mL predilute ready-to-use | 478M-97 |
| 7.0 mL predilute ready-to-use | 478M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 478M-94-RUO |
| 1.0 mL concentrate (RUO) | 478M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 478M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 478M-98-RUO |
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