MDM2 (IF2) Mouse Monoclonal Antibody
Specialties: Soft Tissue Pathology
Mouse double minute protein 2 (MDM2) is a gene encoded on the 12q13-14 chromosomal sequence.1-5 It encodes for a 483 amino acid residue protein which binds to the amino-terminal transcription region of p53.2,5 MDM2 has been shown to negatively regulate the tumor-suppressor activity of p53 by three mechanisms: Blocking p53 transcription, binding to p53 causing it to be exported from the nucleus, and accelerating the destruction of p53.1 MDM2 up-regulation has been shown in liposarcoma while being absent in lipoma.2,4 Therefore, anti-MDM2 has been demonstrated to be a potentially useful tool in distinguishing well-differentiated liposarcoma (atypical lipomatous tumor) from lipoma, with the neoplastic cells positive in the former lesion and negative in lipoma.2,4
- Uhrinova S, et al. Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding. J Mol Biol. 2005; 350:587-98.
- Arici A, et al. Immunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classification. Indian J Cancer. 2013; 50:164-9.
- Ware PL, et al. MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors. Am J Clin Pathol. 2014; 141:334-41.
- Binh MB, et al. Reproducibility of MDM2 and CDK4 staining in soft tissue tumors. Am J Clin Pathol. 2006; 125:693-7.
- Momand J, et al. The MDM2 gene amplification database. Nucleic Acids Res. 1998; 26:3453-9.
Specifications
- Reactivity: paraffin
- Control: Well-differentiated liposarcoma (Nuclear); Dedifferentiated liposarcoma (Nuclear)
- Dilution Range: 1:25-1:50 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC47929000)
Have a different keycode?
Click Here
Learn how to obtain your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 479M-94 |
| 0.5 mL concentrate | 479M-95 |
| 1.0 mL concentrate | 479M-96 |
| 1.0 mL predilute ready-to-use | 479M-97 |
| 7.0 mL predilute ready-to-use | 479M-98 |
For research use only (RUO) in Canada
| 0.1 mL concentrate (RUO) | 479M-94-RUO |
| 1.0 mL concentrate (RUO) | 479M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 479M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 479M-98-RUO |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 479M-94 |
| 0.5 mL concentrate | 479M-95 |
| 1.0 mL concentrate | 479M-96 |
| 1.0 mL predilute ready-to-use | 479M-97 |
| 7.0 mL predilute ready-to-use | 479M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 479M-94-RUO |
| 1.0 mL concentrate (RUO) | 479M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 479M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 479M-98-RUO |
To request information on this product in additional countries, please click the button below.
