CD71 (EP232) Rabbit Monoclonal Antibody

CD71
CD71 (EP232) on bone marrow.

CD71 (EP232) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-10-12 16:54:07

Transferrin receptor 1 (CD71) is expressed on placental syncytiotrophoblasts, myocytes, basal keratinocytes, hepatocytes, endocrine pancreas, spermatocytes, and erythroid precursors. The level of transferrin receptor expression is highest in early erythroid precursors through the intermediate normoblast phase, after which expression decreases through the reticulocyte phase. The maturation of erythrocytes results in loss of transferrin receptor expression.  Anti-CD71 is useful in identifying erythroid precursors. The high level of transferrin receptor within erythroid precursors makes anti-CD71 an excellent marker for evaluation of erythroid precursors within bone marrow biopsy specimens and shows the following features: 1) distinct membranous and cytoplasmic staining pattern, which is easily recognized in bone marrow biopsy; 2) restriction to erythroid lineage within bone marrow biopsy specimens; 3) CD71 expression decreases with the maturation of erythrocytes, with the highest level seen in early forms and the lowest level in late normoblast stage, and most importantly; 4) mature erythrocytes do not express CD71.1-5

  1. Ponka P, et al. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol. 1999; 31:1111-37.
  2. Sieff C, et al. Changes in cell surface antigen expression during hemopoietic differentiation. Blood. 1982; 60:703-13.
  3. Lesley J, et al. Expression of transferrin receptor on murine hematopoietic progenitors. Cell Immunol. 1984; 83:14-25.
  4. Nakahata T, et al. Cell surface antigen expression in human erythroid progenitors: erythroid and megakaryocytic markers. Leuk Lymphoma. 1994; 13:401-9.
  5. Marsee DK, et al. CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens. Am J Clin Pathol. 2010; 134:429-35.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: bone marrow
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate171R-14
0.5 mL concentrate171R-15
1 mL concentrate171R-16
1 mL predilute171R-17
7 mL predilute171R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate171R-14
0.5 mL concentrate171R-15
1 mL concentrate171R-16
1 mL predilute171R-17
7 mL predilute171R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate171R-14
0.5 mL concentrate171R-15
1 mL concentrate171R-16
1 mL predilute171R-17
7 mL predilute171R-18

For research use only (RUO) in Japan

0.1 mL concentrate171R-14-RUO
0.5 mL concentrate171R-15-RUO
1 mL concentrate171R-16-RUO
1 mL predilute171R-17-RUO
7 mL predilute171R-18-RUO

 

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