CD35 (EP197) Rabbit Monoclonal Antibody

CD35
CD35 (EP197) on follicular dendritic cell sarcoma

CD35 (EP197) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology Hematopathology

Updated: 2017-10-12 16:53:50

CD35, complement receptor 1, is a cell membrane-bound, monomeric glycoprotein on numerous cell types including erythrocytes, leukocytes, glomerular podocytes, and follicular dendritic cells. The primary function of CD35 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. CD35 antigen is found on erythrocytes, B cells, a subset of T cells, monocytes, as well as eosinophils, and neutrophils. Anti-CD35 is considered a mature B-cell marker which labels follicular dendritic reticulum cells and tumors derived from such cells such as follicular dendritic cell tumor/sarcoma.1-6

  1. Dillon KM, et al. Mediastinal mixed dendritic cell sarcoma with hybrid features. J Clin Pathol. 2002; 55:791-4.
  2. Pileri SA, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology. 2002; 41:1-29.
  3. Maeda K, et al. Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections. J Histochem Cytochem. 2002; 50:1475-86.
  4. Biddle DA, et al. Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature. Mod Pathol 2002; 15:50-8.
  5. Cheuk W, et al. Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association. Am J Surg Pathol. 200; 25:721-31.
  6. Chang KC, et al. Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma. J Pathol. 2003; 201:404-12.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate135R-14
0.5 mL concentrate135R-15
1 mL concentrate135R-16
1 mL predilute135R-17
7 mL predilute135R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate135R-14
0.5 mL concentrate135R-15
1 mL concentrate135R-16
1 mL predilute135R-17
7 mL predilute135R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate135R-14
0.5 mL concentrate135R-15
1 mL concentrate135R-16
1 mL predilute135R-17
7 mL predilute135R-18

For research use only (RUO) in Japan

0.1 mL concentrate135R-14-RUO
0.5 mL concentrate135R-15-RUO
1 mL concentrate135R-16-RUO
1 mL predilute135R-17-RUO
7 mL predilute135R-18-RUO

 

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