Nerve Growth Factor Receptor (NGFR) (EP31) Rabbit Monoclonal Antibody

Nerve Growth Factor Receptor (NGFR)
Nerve Growth Factor Receptor (NGFR) (EP31) on desmoplastic melanoma.

Nerve Growth Factor Receptor (NGFR) (EP31) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology Dermatopathology

Updated: 2017-10-12 16:55:00

Nerve Growth Factor Receptor (NGFR), a 75 kd glycoprotein (also known as P-75NTR), is the first of neurotrophin receptors to be isolated and is a member of the tumor necrosis factor (TNF) receptor family. NGFR is expressed not only in sympathetic and sensory neurons, but also in various neural crest cell or tumor derivatives such as melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, and neurotized nevi (type C melanocytes). Anti-NGFR has been shown to be a reliable marker for desmoplastic and neurotropic melanoma. Expression of NGFR is ubiquitous and not limited to the nervous system, being expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR labels the myoepithelial cells of breast ducts and intralobular fibroblasts, and thus, is an aid in identifying invasive lesions in the breast.1-6

  1. Reis-Filho JS, et al. Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue. Mod Pathol. 2006; 2:307-19.
  2. Lewis Kelso R, et al. p75(NGFR) immunostaining for the detection of perineural invasion by cutaneous squamous cell carcinoma. Dermatol Surg. 2006; 32:177-83.
  3. Liang Y, et al. Light and electron microscopic demonstration of the p75 nerve growth factor receptor in normal human cutaneous nerve fibers: new vistas. J Invest Dermatol. 1998; 111:114-8.
  4. Liang Y, et al. Histamine-containing mast cells and their relationship to NGFr-immunoreactive nerves in prurigo nodularis: a reappraisal. J Cutan Pathol. 1998; 25:189-98.
  5. Liang Y, et al. Light and electron microscopic immunohistochemical observations of p75 nerve growth factor receptor-immunoreactive dermal nerves in prurigo nodularis. Arch Dermatol Res. 1999; 291:14-21.
  6. Otaibi S, et al. NGFR (p75) expression in cutaneous scars. Further evidence for a potential pitfall in evaluation of reexcision scars of cutaneous neoplasms, in particular desmoplastic melanoma. Am J Dermatopathol. 2011; 33:65-71.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: breast
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate304R-14
0.5 mL concentrate304R-15
1 mL concentrate304R-16
1 mL predilute304R-17
7 mL predilute304R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate304R-14
0.5 mL concentrate304R-15
1 mL concentrate304R-16
1 mL predilute304R-17
7 mL predilute304R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate304R-14
0.5 mL concentrate304R-15
1 mL concentrate304R-16
1 mL predilute304R-17
7 mL predilute304R-18

For research use only (RUO) in Japan

0.1 mL concentrate304R-14-RUO
0.5 mL concentrate304R-15-RUO
1 mL concentrate304R-16-RUO
1 mL predilute304R-17-RUO
7 mL predilute304R-18-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information