PD-1 (EP239) Rabbit Monoclonal Antibody

PD-1
PD-1 (EP239) on Angioimmunoblastic T-cell lymphoma.

PD-1 (EP239) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology Hematopathology

Updated: 2017-10-12 16:49:24

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1 is expressed by few B-cells, so anti-PD-1 may be a more specific and useful marker in the identification of angioimmunoblastic lymphoma. In addition, PD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. PD-1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T-cells may undergo neoplastic transformation and result in specific distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.1-6

  1. Bolstad AI, et al. Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lympho­cyte-associated antigen 4, and programmed cell death 1 in primary Sjögren’s syndrome. Arthritis Rheum. 2003; 48:174-85.
  2. Kobayashi M, et al. Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjögren’s syndrome. J Rheumatol. 2005; 32:2156-63.
  3. Hamanishi J, et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci U S A. 2007; 104:3360-5.
  4. Iwai Y, et al. Microanatomical localization of PD-1 in human tonsils. Immunol Lett. 2002; 83:215-20.
  5. Dorfman DM, et al. Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol. 2006; 30:802-10
  6. Konishi J, et al. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res. 2004; 10:5094-100.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: lymph node, tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate315R-14
0.5 mL concentrate315R-15
1 mL concentrate315R-16
1 mL predilute315R-17
7 mL predilute315R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate315R-14
0.5 mL concentrate315R-15
1 mL concentrate315R-16
1 mL predilute315R-17
7 mL predilute315R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate315R-14
0.5 mL concentrate315R-15
1 mL concentrate315R-16
1 mL predilute315R-17
7 mL predilute315R-18

For research use only (RUO) in Japan

0.1 mL concentrate315R-14-RUO
0.5 mL concentrate315R-15-RUO
1 mL concentrate315R-16-RUO
1 mL predilute315R-17-RUO
7 mL predilute315R-18-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information