LIN28 (EP150) Rabbit Monoclonal Antibody

LIN28
LIN28 (EP150) on Yolk sac tumor

LIN28 (EP150) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-10-25 09:39:43

LIN-28 is a RNA-binding protein that acts as an inhibitor of let-7 tumor suppressor microRNAs, and posttranscriptional regulator of mRNAs involved in the renewal and development of embryonic stem cells.1-5 Anti-LIN28 reactivity is seen in extragonadal seminomas/germinomas, embryonal carcinoma, teratomas, and yolk sac tumors. Anti-LIN28 reactivity is only seen in a small fraction of various extragonadal-non-germ cell tumors, and adult testis tissues. Therefore, Anti-LIN28 is a useful marker in the differential identification of germ cell tumors and cancers of non-germ cell origin.6-12

  1. Peng S, et al. Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells. Stem Cells. 2011; 29:496-504.
  2. Zhu H, et al. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011; 147:81-94.
  3. Tsialikas J, et al. LIN28: roles and regulation in development and beyond. Development. 2015; 142:2397-404.
  4. Nguyen LH, et al. Lin28 and let-7 in cell metabolism and cancer. Transl Pediatr. 2015; 4:4-11.
  5. Viswanathan SR, et al. Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009; 41:843-8.
  6. West JA, et al. A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature. 2009; 460:909-13.
  7. Cao D, et al. RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases. Mod Pathol. 2011; 24:288-96.
  8. Nogales FF, et al. A diagnostic immunohistochemical panel for yolk sac (primitive endodermal) tumours based on an immunohistochemical comparison with the human yolk sac. Histopathology. 2014; 65:51-9.
  9. Cao D, et al. RNA-binding protein LIN28 is a marker for testicular germ cell tumors. Hum Pathol. 2011; 42:710-8.
  10. Xue D, et al. RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours. Histopathology. 2011; 59:452-9.
  11. Gillis AJ, et al. Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis. Int J Androl. 2011; 34:e160-174.
  12. Aeckerle N, et al. The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells? Mol Hum Reprod. 2012; 18:477-88.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, nuclear
  • Control: yolk sac tumor, embryonal carcinoma, seminoma, dysgerminoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate464R-14
0.5 mL concentrate464R-15
1 mL concentrate464R-16
1 mL predilute464R-17
7 mL predilute464R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate464R-14
0.5 mL concentrate464R-15
1 mL concentrate464R-16
1 mL predilute464R-17
7 mL predilute464R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate464R-14
0.5 mL concentrate464R-15
1 mL concentrate464R-16
1 mL predilute464R-17
7 mL predilute464R-18

For research use only (RUO) in Japan

0.1 mL concentrate464R-14-RUO
0.5 mL concentrate464R-15-RUO
1 mL concentrate464R-16-RUO
1 mL predilute464R-17-RUO
7 mL predilute464R-18-RUO

 

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