Desmoglein 3 (EP306) Rabbit Monoclonal Antibody

Desmoglein 3
Desmoglein 3 (EP306) on lung squamous cell carcinoma

Desmoglein 3 (EP306) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-10-25 09:39:14

Desmosomes are cell to cell adhesion complexes that provide mechanical integrity to keratinocytes by linking to keratin intermediate filaments.1,2 Desmosomes are made up of two major transmembrane proteins known as desmoglein (DSG) and desmocollin.1 Three DSG subfamily members have been identified-DSG1, DSG2, and DSG3.2 DSG3 makes up the calcium binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells.2 DSG3 is found in both the basal and suprabasal layers of the stratified epithelia. DSG3 has been found to be expressed in squamous carcinomas of the lung, bladder, skin, and urinary system among others.1,2 DSG3 is a highly specific marker for labeling squamous differentiation and can be used to help identify a squamous component in carcinomas.1 DSG3 is a reliable marker for differentiating lung squamous cell carcinoma from lung adenocarcinoma.1,2

  1. Huang W, et al. Novel markers of squamous differentiation in the urinary bladder. Hum Pathol. 2013; 44:1989-97.
  2. Tacha D, et al. A 6-antibody panel for the classification of lung adenocarcinoma versus squamous cell carcinoma. Appl Immunohistochem Mol Morphol. 2012; 20:201-7.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: lung squamous cell carcinoma, skin squamous cell carcinoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate436R-14
0.5 mL concentrate436R-15
1 mL concentrate436R-16
1 mL predilute436R-17
7 mL predilute436R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate436R-14
0.5 mL concentrate436R-15
1 mL concentrate436R-16
1 mL predilute436R-17
7 mL predilute436R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate436R-14
0.5 mL concentrate436R-15
1 mL concentrate436R-16
1 mL predilute436R-17
7 mL predilute436R-18

For research use only (RUO) in Japan

0.1 mL concentrate436R-14-RUO
0.5 mL concentrate436R-15-RUO
1 mL concentrate436R-16-RUO
1 mL predilute436R-17-RUO
7 mL predilute436R-18-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information