CD74 (EP167) Rabbit Monoclonal Antibody

CD74
CD74 (EP167) on small lymphocytic lymphoma.

CD74 (EP167) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

The CD74 antigen represents a membrane-bound subunit of the MHC Class II-associated invariant chain that is encoded by the gene located on Chromosome 5.  The antibody recognizes nuclear and cytoplasmic antigens of MW 35 kD and 31 kD respectively.  Anti-CD74 stains predominantly germinal center lymphocytes and those in the mantle cell region of the lymph node. It stains the cell membrane but a paranuclear globular labeling is also noted.  Plasma cells are not labeled.  Thymocytes are negative but dendritic cells are often labeled by anti-CD74. Anti-CD74 labels about 90% of low grade B-cell lymphomas and 20% of low grade T-cell lymphomas.  In high-grade lymphomas the discriminatory power (B-cell vs. T-cell) is diminished.  Reed-Sternberg cells are also labeled in approximately 60% of cases.1

  1. Leong A S-Y, et al. London, England: Greenwich Medical Media Ltd., 1999. Print.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: tonsil, lymph node
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate174R-14
0.5 mL concentrate174R-15
1 mL concentrate174R-16
1 mL predilute174R-17
7 mL predilute174R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate174R-14
0.5 mL concentrate174R-15
1 mL concentrate174R-16
1 mL predilute174R-17
7 mL predilute174R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate174R-14
0.5 mL concentrate174R-15
1 mL concentrate174R-16
1 mL predilute174R-17
7 mL predilute174R-18

For research use only (RUO) in Japan

0.1 mL concentrate174R-14-RUO
0.5 mL concentrate174R-15-RUO
1 mL concentrate174R-16-RUO
1 mL predilute174R-17-RUO
7 mL predilute174R-18-RUO

 

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