CD23 (EP75) Rabbit Monoclonal Antibody

CD23
CD23 (EP75) on small lymphocytic lymphoma.

CD23 (EP75) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease.1  Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly.2 The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive.CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL).

  1. Rowlands DC, et al. Journal of Pathology. 1990; 160:239-43.
  2. DiRaimondo F, et al. Cancer. 2002; 94:1721-30.
  3. Raghoebier S, et al. Blood. 1991; 78:2680-5.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil, lymph node, chronic lymphocytic leukemia, small lymphocytic lymphoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate123R-24
0.5 mL concentrate123R-25
1 mL concentrate123R-26
1 mL predilute123R-27
7 mL predilute123R-28

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate123R-24
0.5 mL concentrate123R-25
1 mL concentrate123R-26
1 mL predilute123R-27
7 mL predilute123R-28

For research use only (RUO) in the EU

0.1 mL concentrate123R-24-RUO
0.5 mL concentrate123R-25-RUO
1 mL concentrate123R-26-RUO
1 mL predilute123R-27-RUO
7 mL predilute123R-28-RUO

For research use only (RUO) in Japan

0.1 mL concentrate123R-24-RUO
0.5 mL concentrate123R-25-RUO
1 mL concentrate123R-26-RUO
1 mL predilute123R-27-RUO
7 mL predilute123R-28-RUO

 

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