Parvalbumin (EP300) Rabbit Monoclonal Antibody

Parvalbumin
Parvalbumin (EP300) on chromophobe renal cell carcinoma.

Parvalbumin (EP300) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Parvalbumin is a calcium-binding protein that regulates cytosolic calcium homeostasis.1-2 Tissue types that express this protein have been reported in the muscle, brain, neuroendocrine organs, and kidney.1-2 In normal kidney, parvalbumin has been shown to be limited to the distal tubular and collecting duct cells (the intercalated cells).1-3 Parvalbumin is strongly expressed in almost all primary, as well as metastatic, chromophobe renal cell carcinoma (RCC) (100%) and oncocytoma (69%), but is essentially negative in other types of RCCs, such as clear cell RCC and papillary RCC.1-4 This limited expression has been considered in keeping with the putative histogenesis of chromophobe RCC and oncocytoma from the distal portion of the nephron and may facilitate in their differential diagnoses.1-4

  1. Adley BP, et al. Anal Quant Cytol Histol. 2006; 28: 228-36.
  2. Young AN, et al. Am J Surg Pathol. 2003; 27:199-205.
  3. Martignoni G, et al. Mod Pathol. 2001; 1:760-7.
  4. Teresa P, et al. Diagn Cytopathol. 2012; 40:56-61.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: chromophobe renal cell carcinoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate396R-14
0.5 mL concentrate396R-15
1 mL concentrate396R-16
1 mL predilute396R-17
7 mL predilute396R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate396R-14
0.5 mL concentrate396R-15
1 mL concentrate396R-16
1 mL predilute396R-17
7 mL predilute396R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate396R-14
0.5 mL concentrate396R-15
1 mL concentrate396R-16
1 mL predilute396R-17
7 mL predilute396R-18

For research use only (RUO) in Japan

0.1 mL concentrate396R-14-RUO
0.5 mL concentrate396R-15-RUO
1 mL concentrate396R-16-RUO
1 mL predilute396R-17-RUO
7 mL predilute396R-18-RUO

 

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