TdT (EP266) Rabbit Monoclonal Antibody

TdT
TdT (EP266) on thymus.

TdT (EP266) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerase that adds nucleotides randomly to single-stranded DNA. This randomization plays a role in acquired immunity by increasing antigen receptor diversity and aiding in the generation of immunoglobulins and T-cell antigen receptors.1 TdT expression is characteristic of lymphoid progenitor cells in thymus and tonsils.2 Anti-TdT is a useful marker for lymphoblastic lymphomas3 and has been observed in some cases of acute myeloid leukemia.4

  1. Motea EA, et al. Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase. Biochimica et Biophysica Acta. 2010; 1804:1151-66.
  2. Stauchen JA, et al. Lymphoid progenitor cells in human tonsils. Int J Surg Pathol. 2003; 11:21-4.
  3. Suzumiya J, et al. Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. J Pathol. 1997; 182:86-91.
  4. Arber DA, et al. Paraffin section immunophenotyping of acute leukemias in bone marrow specimens. Am J Clin Pathol. 1996; 106:462-8.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: thymus
  • Dilution Range: 1:50-1:200*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate338R-24
0.5 mL concentrate338R-25
1 mL concentrate338R-26
1 mL predilute338R-27
7 mL predilute338R-28

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate338R-24
0.5 mL concentrate338R-25
1 mL concentrate338R-26
1 mL predilute338R-27
7 mL predilute338R-28

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate338R-24
0.5 mL concentrate338R-25
1 mL concentrate338R-26
1 mL predilute338R-27
7 mL predilute338R-28

For research use only (RUO) in Japan

0.1 mL concentrate338R-24-RUO
0.5 mL concentrate338R-25-RUO
1 mL concentrate338R-26-RUO
1 mL predilute338R-27-RUO
7 mL predilute338R-28-RUO

 

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