LEF1 (EP310) Rabbit Monoclonal Antibody

LEF1
LEF1 (EP310) on small lymphocytic lymphoma.

LEF1 (EP310) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor that belongs to the TCF/LEF family.1  LEF1 participates as a regulator in Wnt signaling pathways. LEF1 is an important factor in lymphopoiesis and is expressed normally in T and pro-B cells but not expressed in mature B cells.2 Strong nuclear expression of LEF1 has been observed in majority of chronic lymphocytic leukemia/small lymphocytic lymphoma cases and LEF1 is not detected in other small B cell lymphomas.2,3 Anti-LEF1 may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.2,3 

  1. Granic K, et al. Developmental Biology. 2006; 295:219-31.
  2. Tando B, et al. Modern Pathology. 2011; 24:1433-43.
  3. Gandhirajan RK, et al. Neoplasia. 2010; 12:326-35.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: tonsil, small lymphocytic lymphoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate442R-14
0.5 mL concentrate442R-15
1 mL concentrate442R-16
1 mL predilute442R-17
7 mL predilute442R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate442R-14
0.5 mL concentrate442R-15
1 mL concentrate442R-16
1 mL predilute442R-17
7 mL predilute442R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate442R-14
0.5 mL concentrate442R-15
1 mL concentrate442R-16
1 mL predilute442R-17
7 mL predilute442R-18

For research use only (RUO) in Japan

0.1 mL concentrate442R-14-RUO
0.5 mL concentrate442R-15-RUO
1 mL concentrate442R-16-RUO
1 mL predilute442R-17-RUO
7 mL predilute442R-18-RUO

 

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