PHOX2B (EP312) Rabbit Monoclonal Antibody

PHOX2B
PHOX2B (EP312) on neuroblastoma.

PHOX2B (EP312) Rabbit Monoclonal Antibody

Specialties: Neuropathology Pediatric Pathology

Updated: 2017-05-24 08:46:09

Paired-like homeobox 2B (PHOX2B) is a transcription factor located on chromosome 4p135 which is crucial to the formation of autonomic ganglia in the autonomic nervous system (ANS). PHOX2B gene is strictly expressed in neural crest derivatives committed to the noradrenergic phenotype.2 The PHOX2B gene encodes a paired-like homeo-domain transcription factor with an extra-axial expression pattern restricted to the ANS.1,3-4 Neuroblasts of peripheral neuroblastic tumors are derived from the sympathoadrenal lineage, a division of the ANS. PHOX2B has been observed in peripheral neuroblastic tumors, neuroblastomas, paragangliomas, ganglioneuroblastomas, ganglioneuromas and pheochromocytomas.3,5 PHOX2B has been reported to be negative in other small round blue cell tumors.3

  1. Bourdeaut F, et al. Cancer Lett. 2005; 228:51-58.
  2. Pattyn A, et al. Nature. 1999; 399:366-70.
  3. Bielle F, et al. Am J Surg Pathol. 2012; 36:1141-49.
  4. Longo L, et al. Int J Oncol. 2008; 33:985-91.
  5. Nonaka D, et al. Am J Surg Pathol. 2013; 37:1236-41.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: neuroblastoma
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate422R-14
0.5 mL concentrate422R-15
1 mL concentrate422R-16
1 mL predilute422R-17
7 mL predilute422R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate422R-14
0.5 mL concentrate422R-15
1 mL concentrate422R-16
1 mL predilute422R-17
7 mL predilute422R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate422R-14
0.5 mL concentrate422R-15
1 mL concentrate422R-16
1 mL predilute422R-17
7 mL predilute422R-18

For research use only (RUO) in Japan

0.1 mL concentrate422R-14-RUO
0.5 mL concentrate422R-15-RUO
1 mL concentrate422R-16-RUO
1 mL predilute422R-17-RUO
7 mL predilute422R-18-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information